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The impact of physical training on length of hospital stay and physical function in patients hospitalized with community-acquired pneumonia: protocol for a randomized controlled trial

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Ryrsø, Camilla Koch ; Faurholt-Jepsen, Daniel ; Ritz, Christian ; Pedersen, Bente Klarlund ; Hegelund, Maria Hein ; Dungu, Arnold Matovu ; Sejdic, Adin ; Lindegaard, Birgitte ; Krogh-Madsen, Rikke. / The impact of physical training on length of hospital stay and physical function in patients hospitalized with community-acquired pneumonia : protocol for a randomized controlled trial. I: Trials. 2021 ; Bind 22, Nr. 1. s. 571.

Bibtex

@article{a4c17bdbe9a44429b072f1c6e5a4dadc,
title = "The impact of physical training on length of hospital stay and physical function in patients hospitalized with community-acquired pneumonia: protocol for a randomized controlled trial",
abstract = "BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels of physical activity is common during periods of hospitalization and leads to functional decline as well as increased risk of complications. The aim of this study is to assess the effect of supervised physical training during hospitalization with CAP compared with standard usual care for CAP on length of hospital stay, risk of readmission, mortality risk, physical capacity, muscle and fat mass, muscle strength, metabolic function, systemic inflammation, health-related quality of life, and physical activity level.METHODS: This study is a randomized controlled trial with three parallel experimental arms. Based on a sample size calculation, a total of 210 patients admitted with CAP at Nordsj{\ae}llands Hospital, Hiller{\o}d, Denmark, will be recruited. Patients will be randomly allocated (1:1:1) to either (1) standard usual care, (2) standard usual care combined with in-bed cycling, or (3) standard usual care combined with exercises from a booklet. The primary outcome is differences in length of hospital stay between groups, with secondary outcomes being differences between groups in time to (1) 90-day readmission and (2) 180-day mortality. Further secondary outcomes are differences in changes from baseline between groups in (3) lean mass, (4) fat mass, (5) fat-free mass, (6) physical capacity, (7) health-related quality of life, (8) systemic inflammation, and (9) physical activity level after discharge. Data on length of hospital stay, readmission, and mortality will be collected from patient files, while total lean, fat, and fat-free mass will be quantitated by dual-energy x-ray absorptiometry and bioelectrical impedance analysis. Physical function will be assessed using grip strength, 30-s chair stand tests, and Barthel Index-100. Health-related quality of life will be assessed with the EQ-5D-5L questionnaire. Systemic inflammation will be assessed in blood samples, while accelerometers are used for measuring physical activity.DISCUSSION: If a simple physical training program appears to diminish the impact of critical illness and hospitalization on clinical outcome, mobility, and health-related quality of life, it may lead to novel therapeutic approaches in the treatment of patients hospitalized with CAP.TRIAL REGISTRATION: ClinicalTrials.gov NCT04094636 . Registered on 1 April 2019.",
keywords = "Community-Acquired Infections/diagnosis, Exercise, Humans, Length of Stay, Pneumonia/diagnosis, Quality of Life, Randomized Controlled Trials as Topic, Lean mass, Physical training, Length of hospital stay, Community-acquired pneumonia, Functional ability",
author = "Ryrs{\o}, {Camilla Koch} and Daniel Faurholt-Jepsen and Christian Ritz and Pedersen, {Bente Klarlund} and Hegelund, {Maria Hein} and Dungu, {Arnold Matovu} and Adin Sejdic and Birgitte Lindegaard and Rikke Krogh-Madsen",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
day = "28",
doi = "10.1186/s13063-021-05503-2",
language = "English",
volume = "22",
pages = "571",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - The impact of physical training on length of hospital stay and physical function in patients hospitalized with community-acquired pneumonia

T2 - protocol for a randomized controlled trial

AU - Ryrsø, Camilla Koch

AU - Faurholt-Jepsen, Daniel

AU - Ritz, Christian

AU - Pedersen, Bente Klarlund

AU - Hegelund, Maria Hein

AU - Dungu, Arnold Matovu

AU - Sejdic, Adin

AU - Lindegaard, Birgitte

AU - Krogh-Madsen, Rikke

N1 - © 2021. The Author(s).

PY - 2021/8/28

Y1 - 2021/8/28

N2 - BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels of physical activity is common during periods of hospitalization and leads to functional decline as well as increased risk of complications. The aim of this study is to assess the effect of supervised physical training during hospitalization with CAP compared with standard usual care for CAP on length of hospital stay, risk of readmission, mortality risk, physical capacity, muscle and fat mass, muscle strength, metabolic function, systemic inflammation, health-related quality of life, and physical activity level.METHODS: This study is a randomized controlled trial with three parallel experimental arms. Based on a sample size calculation, a total of 210 patients admitted with CAP at Nordsjællands Hospital, Hillerød, Denmark, will be recruited. Patients will be randomly allocated (1:1:1) to either (1) standard usual care, (2) standard usual care combined with in-bed cycling, or (3) standard usual care combined with exercises from a booklet. The primary outcome is differences in length of hospital stay between groups, with secondary outcomes being differences between groups in time to (1) 90-day readmission and (2) 180-day mortality. Further secondary outcomes are differences in changes from baseline between groups in (3) lean mass, (4) fat mass, (5) fat-free mass, (6) physical capacity, (7) health-related quality of life, (8) systemic inflammation, and (9) physical activity level after discharge. Data on length of hospital stay, readmission, and mortality will be collected from patient files, while total lean, fat, and fat-free mass will be quantitated by dual-energy x-ray absorptiometry and bioelectrical impedance analysis. Physical function will be assessed using grip strength, 30-s chair stand tests, and Barthel Index-100. Health-related quality of life will be assessed with the EQ-5D-5L questionnaire. Systemic inflammation will be assessed in blood samples, while accelerometers are used for measuring physical activity.DISCUSSION: If a simple physical training program appears to diminish the impact of critical illness and hospitalization on clinical outcome, mobility, and health-related quality of life, it may lead to novel therapeutic approaches in the treatment of patients hospitalized with CAP.TRIAL REGISTRATION: ClinicalTrials.gov NCT04094636 . Registered on 1 April 2019.

AB - BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels of physical activity is common during periods of hospitalization and leads to functional decline as well as increased risk of complications. The aim of this study is to assess the effect of supervised physical training during hospitalization with CAP compared with standard usual care for CAP on length of hospital stay, risk of readmission, mortality risk, physical capacity, muscle and fat mass, muscle strength, metabolic function, systemic inflammation, health-related quality of life, and physical activity level.METHODS: This study is a randomized controlled trial with three parallel experimental arms. Based on a sample size calculation, a total of 210 patients admitted with CAP at Nordsjællands Hospital, Hillerød, Denmark, will be recruited. Patients will be randomly allocated (1:1:1) to either (1) standard usual care, (2) standard usual care combined with in-bed cycling, or (3) standard usual care combined with exercises from a booklet. The primary outcome is differences in length of hospital stay between groups, with secondary outcomes being differences between groups in time to (1) 90-day readmission and (2) 180-day mortality. Further secondary outcomes are differences in changes from baseline between groups in (3) lean mass, (4) fat mass, (5) fat-free mass, (6) physical capacity, (7) health-related quality of life, (8) systemic inflammation, and (9) physical activity level after discharge. Data on length of hospital stay, readmission, and mortality will be collected from patient files, while total lean, fat, and fat-free mass will be quantitated by dual-energy x-ray absorptiometry and bioelectrical impedance analysis. Physical function will be assessed using grip strength, 30-s chair stand tests, and Barthel Index-100. Health-related quality of life will be assessed with the EQ-5D-5L questionnaire. Systemic inflammation will be assessed in blood samples, while accelerometers are used for measuring physical activity.DISCUSSION: If a simple physical training program appears to diminish the impact of critical illness and hospitalization on clinical outcome, mobility, and health-related quality of life, it may lead to novel therapeutic approaches in the treatment of patients hospitalized with CAP.TRIAL REGISTRATION: ClinicalTrials.gov NCT04094636 . Registered on 1 April 2019.

KW - Community-Acquired Infections/diagnosis

KW - Exercise

KW - Humans

KW - Length of Stay

KW - Pneumonia/diagnosis

KW - Quality of Life

KW - Randomized Controlled Trials as Topic

KW - Lean mass

KW - Physical training

KW - Length of hospital stay

KW - Community-acquired pneumonia

KW - Functional ability

UR - http://www.scopus.com/inward/record.url?scp=85113612777&partnerID=8YFLogxK

U2 - 10.1186/s13063-021-05503-2

DO - 10.1186/s13063-021-05503-2

M3 - Journal article

C2 - 34454594

VL - 22

SP - 571

JO - Trials

JF - Trials

SN - 1745-6215

IS - 1

M1 - 571

ER -

ID: 67445718