Udskriv Udskriv
Switch language
Hvidovre Hospital - en del af Københavns Universitetshospital

The global dissemination of hospital clones of Enterococcus faecium

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review


  • Sebastiaan J van Hal
  • Rob J L Willems
  • Theodore Gouliouris
  • Susan A Ballard
  • Teresa M Coque
  • Anette M Hammerum
  • Kristin Hegstad
  • Hendrik Westh
  • Benjamin P Howden
  • Surbhi Malhotra-Kumar
  • Guido Werner
  • Katsunori Yanagihara
  • Ashlee M Earl
  • Katherine E Raven
  • Jukka Corander
  • Rory Bowden
  • Enterococcal Group
Vis graf over relationer

BACKGROUND: The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood.

METHODS: A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of Enterococcus faecium was assembled (n = 973). We analysed, using a novel analysis approach, global diversity in terms of both the dynamics of the accessory genome and homologous recombination among conserved genes.

RESULTS: Two main modes of genomic evolution continue to shape E. faecium: the acquisition and loss of genes, including antimicrobial resistance genes, through mobile genetic elements including plasmids, and homologous recombination of the core genome. These events lead to new clones emerging at the local level, followed by the erosion of signals of clonality through recombination, and in some identifiable cases producing new clonal clusters. These patterns lead to new, emerging lineages which are able to spread globally over relatively short timeframes.

CONCLUSIONS: The ability of A1 E. faecium to continually present new combinations of genes for potential selection suggests that controlling this pathogen will remain challenging but establishing a framework for understanding genomic evolution is likely to aid in tracking the threats posed by newly emerging lineages.

TidsskriftGenome Medicine
Udgave nummer1
Sider (fra-til)52
StatusUdgivet - 30 mar. 2021

ID: 68198412