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Successful Use of a GLP-1 Receptor Agonist as Add-on Therapy to Sulfonylurea in the Treatment of KCNJ11 Neonatal Diabetes

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@article{655d387a0e194cf1bffe90a96b8d491c,
title = "Successful Use of a GLP-1 Receptor Agonist as Add-on Therapy to Sulfonylurea in the Treatment of KCNJ11 Neonatal Diabetes",
abstract = "Sulfonylurea monotherapy is the standard treatment for patients with the most common form of permanent neonatal diabetes, KCNJ11 neonatal diabetes, but it is not always sufficient. For the first time, we present a case of successful use of a GLP-1 receptor agonist as add-on therapy in the treatment of a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy. Good glycaemic control was maintained with a HbA1c level of 48 mmol/mol (6.5%) at the end of 26 months' follow-up.LEARNING POINTS: Genetic testing is important in patients with neonatal diabetes.Sulfonylurea is the standard treatment for patients with the most common mutation (KCNJ11).We present the novel use of a GLP-1 receptor agonist as effective add-on therapy in a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy.",
author = "Morten Hinds{\o} and Christoffer Martinussen and Svane, {Maria Saur} and Simon Veedfald and Birthe Gade-Rasmussen and Torben Hansen and Sten Madsbad",
note = "{\textcopyright} EFIM 2021.",
year = "2021",
month = mar,
day = "31",
doi = "10.12890/2021_002352",
language = "English",
volume = "8",
pages = "1--4",
journal = "European journal of case reports in internal medicine",
issn = "2284-2594",
publisher = "SMC Media Srl",
number = "3",

}

RIS

TY - JOUR

T1 - Successful Use of a GLP-1 Receptor Agonist as Add-on Therapy to Sulfonylurea in the Treatment of KCNJ11 Neonatal Diabetes

AU - Hindsø, Morten

AU - Martinussen, Christoffer

AU - Svane, Maria Saur

AU - Veedfald, Simon

AU - Gade-Rasmussen, Birthe

AU - Hansen, Torben

AU - Madsbad, Sten

N1 - © EFIM 2021.

PY - 2021/3/31

Y1 - 2021/3/31

N2 - Sulfonylurea monotherapy is the standard treatment for patients with the most common form of permanent neonatal diabetes, KCNJ11 neonatal diabetes, but it is not always sufficient. For the first time, we present a case of successful use of a GLP-1 receptor agonist as add-on therapy in the treatment of a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy. Good glycaemic control was maintained with a HbA1c level of 48 mmol/mol (6.5%) at the end of 26 months' follow-up.LEARNING POINTS: Genetic testing is important in patients with neonatal diabetes.Sulfonylurea is the standard treatment for patients with the most common mutation (KCNJ11).We present the novel use of a GLP-1 receptor agonist as effective add-on therapy in a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy.

AB - Sulfonylurea monotherapy is the standard treatment for patients with the most common form of permanent neonatal diabetes, KCNJ11 neonatal diabetes, but it is not always sufficient. For the first time, we present a case of successful use of a GLP-1 receptor agonist as add-on therapy in the treatment of a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy. Good glycaemic control was maintained with a HbA1c level of 48 mmol/mol (6.5%) at the end of 26 months' follow-up.LEARNING POINTS: Genetic testing is important in patients with neonatal diabetes.Sulfonylurea is the standard treatment for patients with the most common mutation (KCNJ11).We present the novel use of a GLP-1 receptor agonist as effective add-on therapy in a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy.

U2 - 10.12890/2021_002352

DO - 10.12890/2021_002352

M3 - Journal article

C2 - 33869096

VL - 8

SP - 1

EP - 4

JO - European journal of case reports in internal medicine

JF - European journal of case reports in internal medicine

SN - 2284-2594

IS - 3

M1 - 002352

ER -

ID: 65018065