Forskning
Udskriv Udskriv
Switch language
Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Priskorn, L, Tøttenborg, SS, Almstrup, K, Andersson, A-M, Axelsson, J, Bräuner, EV, Elenkov, A, Freiesleben, NLC, Giwercman, YL, Grøndahl, ML, Hansen, AH, Hansen, LS, Henic, E, Kitlinski, ML, Landersoe, SK, Lindh, C, Løkkegaard, EL, Malm, J, Olsen, KW, Petersen, KU, Schmidt, L, Stormlund, S, Svendsen, PF, Vassard, D, Wang, NF, Zedeler, A, Bhasin, S, Chavarro, J, Eisenberg, ML, Hauser, R, Huhtaniemi, I, Krawetz, SA, Marko-Varga, G, Salonia, A, Toppari, J, Juul, A, Jørgensen, N, Nielsen, HS, Pinborg, A, Rylander, L & Giwercman, A 2021, 'RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity', Andrology, bind 9, nr. 6, 13063, s. 1828-1842. https://doi.org/10.1111/andr.13063

APA

Priskorn, L., Tøttenborg, S. S., Almstrup, K., Andersson, A-M., Axelsson, J., Bräuner, E. V., Elenkov, A., Freiesleben, N. L. C., Giwercman, Y. L., Grøndahl, M. L., Hansen, A. H., Hansen, L. S., Henic, E., Kitlinski, M. L., Landersoe, S. K., Lindh, C., Løkkegaard, E. L., Malm, J., Olsen, K. W., ... Giwercman, A. (2021). RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity. Andrology, 9(6), 1828-1842. [13063]. https://doi.org/10.1111/andr.13063

CBE

Priskorn L, Tøttenborg SS, Almstrup K, Andersson A-M, Axelsson J, Bräuner EV, Elenkov A, Freiesleben NLC, Giwercman YL, Grøndahl ML, Hansen AH, Hansen LS, Henic E, Kitlinski ML, Landersoe SK, Lindh C, Løkkegaard EL, Malm J, Olsen KW, Petersen KU, Schmidt L, Stormlund S, Svendsen PF, Vassard D, Wang NF, Zedeler A, Bhasin S, Chavarro J, Eisenberg ML, Hauser R, Huhtaniemi I, Krawetz SA, Marko-Varga G, Salonia A, Toppari J, Juul A, Jørgensen N, Nielsen HS, Pinborg A, Rylander L, Giwercman A. 2021. RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity. Andrology. 9(6):1828-1842. https://doi.org/10.1111/andr.13063

MLA

Vancouver

Author

Priskorn, Laerke ; Tøttenborg, Sandra Søgaard ; Almstrup, Kristian ; Andersson, Anna-Maria ; Axelsson, Jonatan ; Bräuner, Elvira Vaclavik ; Elenkov, Angel ; Freiesleben, Nina la Cour ; Giwercman, Yvonne Lundberg ; Grøndahl, Marie Louise ; Hansen, Ann Holm ; Hansen, Laura Smidt ; Henic, Emir ; Kitlinski, Margareta Laczna ; Landersoe, Selma Kloeve ; Lindh, Christian ; Løkkegaard, Ellen Leth ; Malm, Johan ; Olsen, Kristina Wendelboe ; Petersen, Kajsa Uglevig ; Schmidt, Lone ; Stormlund, Sacha ; Svendsen, Pernille Fog ; Vassard, Ditte ; Wang, Nathalie Friis ; Zedeler, Anne ; Bhasin, Shalender ; Chavarro, Jorge ; Eisenberg, Michael L ; Hauser, Russ ; Huhtaniemi, Ilpo ; Krawetz, Stephen A ; Marko-Varga, György ; Salonia, Andrea ; Toppari, Jorma ; Juul, Anders ; Jørgensen, Niels ; Nielsen, Henriette Svarre ; Pinborg, Anja ; Rylander, Lars ; Giwercman, Aleksander. / RUBIC (ReproUnion Biobank and Infertility Cohort) : A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity. I: Andrology. 2021 ; Bind 9, Nr. 6. s. 1828-1842.

Bibtex

@article{6294c7f2872a4bfea130536c8fdcbb7a,
title = "RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity",
abstract = "Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Sk{\aa}ne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.",
keywords = "epigenetics, human microbiome/microbiota, infertility, medically assisted reproduction, reproductive disorders, semen quality",
author = "Laerke Priskorn and T{\o}ttenborg, {Sandra S{\o}gaard} and Kristian Almstrup and Anna-Maria Andersson and Jonatan Axelsson and Br{\"a}uner, {Elvira Vaclavik} and Angel Elenkov and Freiesleben, {Nina la Cour} and Giwercman, {Yvonne Lundberg} and Gr{\o}ndahl, {Marie Louise} and Hansen, {Ann Holm} and Hansen, {Laura Smidt} and Emir Henic and Kitlinski, {Margareta Laczna} and Landersoe, {Selma Kloeve} and Christian Lindh and L{\o}kkegaard, {Ellen Leth} and Johan Malm and Olsen, {Kristina Wendelboe} and Petersen, {Kajsa Uglevig} and Lone Schmidt and Sacha Stormlund and Svendsen, {Pernille Fog} and Ditte Vassard and Wang, {Nathalie Friis} and Anne Zedeler and Shalender Bhasin and Jorge Chavarro and Eisenberg, {Michael L} and Russ Hauser and Ilpo Huhtaniemi and Krawetz, {Stephen A} and Gy{\"o}rgy Marko-Varga and Andrea Salonia and Jorma Toppari and Anders Juul and Niels J{\o}rgensen and Nielsen, {Henriette Svarre} and Anja Pinborg and Lars Rylander and Aleksander Giwercman",
note = "{\textcopyright} 2021 American Society of Andrology and European Academy of Andrology.",
year = "2021",
month = nov,
doi = "10.1111/andr.13063",
language = "English",
volume = "9",
pages = "1828--1842",
journal = "Andrology",
issn = "2047-2919",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - RUBIC (ReproUnion Biobank and Infertility Cohort)

T2 - A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity

AU - Priskorn, Laerke

AU - Tøttenborg, Sandra Søgaard

AU - Almstrup, Kristian

AU - Andersson, Anna-Maria

AU - Axelsson, Jonatan

AU - Bräuner, Elvira Vaclavik

AU - Elenkov, Angel

AU - Freiesleben, Nina la Cour

AU - Giwercman, Yvonne Lundberg

AU - Grøndahl, Marie Louise

AU - Hansen, Ann Holm

AU - Hansen, Laura Smidt

AU - Henic, Emir

AU - Kitlinski, Margareta Laczna

AU - Landersoe, Selma Kloeve

AU - Lindh, Christian

AU - Løkkegaard, Ellen Leth

AU - Malm, Johan

AU - Olsen, Kristina Wendelboe

AU - Petersen, Kajsa Uglevig

AU - Schmidt, Lone

AU - Stormlund, Sacha

AU - Svendsen, Pernille Fog

AU - Vassard, Ditte

AU - Wang, Nathalie Friis

AU - Zedeler, Anne

AU - Bhasin, Shalender

AU - Chavarro, Jorge

AU - Eisenberg, Michael L

AU - Hauser, Russ

AU - Huhtaniemi, Ilpo

AU - Krawetz, Stephen A

AU - Marko-Varga, György

AU - Salonia, Andrea

AU - Toppari, Jorma

AU - Juul, Anders

AU - Jørgensen, Niels

AU - Nielsen, Henriette Svarre

AU - Pinborg, Anja

AU - Rylander, Lars

AU - Giwercman, Aleksander

N1 - © 2021 American Society of Andrology and European Academy of Andrology.

PY - 2021/11

Y1 - 2021/11

N2 - Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.

AB - Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.

KW - epigenetics

KW - human microbiome/microbiota

KW - infertility

KW - medically assisted reproduction

KW - reproductive disorders

KW - semen quality

UR - http://www.scopus.com/inward/record.url?scp=85108217849&partnerID=8YFLogxK

U2 - 10.1111/andr.13063

DO - 10.1111/andr.13063

M3 - Journal article

C2 - 34114375

VL - 9

SP - 1828

EP - 1842

JO - Andrology

JF - Andrology

SN - 2047-2919

IS - 6

M1 - 13063

ER -

ID: 66308400