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Risk factors for Staphylococcus aureus bacteremia in patients with rheumatoid arthritis and incidence compared with the general population: protocol for a Danish nationwide observational cohort study

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Dieperink, Sabine Sparre ; Glintborg, Bente ; Oestergaard, Louise Bruun ; Nørgaard, Mette ; Benfield, Thomas ; Mehnert, Frank ; Petersen, Andreas ; Hetland, Merete Lund. / Risk factors for Staphylococcus aureus bacteremia in patients with rheumatoid arthritis and incidence compared with the general population : protocol for a Danish nationwide observational cohort study. I: BMJ Open. 2019 ; Bind 9, Nr. 9. s. e030999.

Bibtex

@article{e5bf40bb538047bfba183134f314fb96,
title = "Risk factors for Staphylococcus aureus bacteremia in patients with rheumatoid arthritis and incidence compared with the general population: protocol for a Danish nationwide observational cohort study",
abstract = "INTRODUCTION: Staphylococcus aureus bacteremia (SAB) is an invasive infection with high mortality and morbidity. Rheumatoid arthritis (RA) is associated with increased risk of infections due to the disease per se and the use of antirheumatic treatments. Few minor studies have previously investigated risk of SAB in patients with RA and indicated increased risk compared with the general population. This nationwide observational study aims to investigate incidence of and risk factors for SAB in adult patients with RA compared with the general population. The effect of disease characteristics (eg, joint erosions, disease duration and activity), different antirheumatic treatments and smoking on SAB risk will be evaluated.METHODS AND ANALYSIS: All adults (>18 years of age) alive and living in Denmark in 1996-2017 will be identified in The Danish Civil Registration System. Incident patients with RA are identified in the Danish National Patient Registry (DNPR) and the nationwide rheumatology registry, DANBIO, in which information on, for example, antirheumatic treatments, disease characteristics and smoking is collected prospectively in routine care. Information on comorbidities, invasive procedures and prescribed drugs are identified in the DNPR and in The Register of Medicinal Product Statistics. Socioeconomic status is evaluated in national registers on income and education. Incident cases of first-time SAB are identified in The Danish National SAB Database. All registers are linked on an individual level by unique civil registration numbers. Incidence rates and incidence rate ratios will be analysed using Poisson regression models and the impact of possible risk factors will be evaluated.ETHICS AND DISSEMINATION: All data will be handled in accordance with the General Data Protection Regulation (EU) 2016/679. No ethical approval is necessary in Denmark when handling registry data only. The results will be presented in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology initiative in international peer-reviewed journals and at medical conferences.TRIAL REGISTRATION NUMBER: NCT03908086.",
keywords = "Antirheumatic agents, Bacteremia, Rheumatoid arthritis, Staphylococcus aureus, Staphylococcus aureus bacteremia",
author = "Dieperink, {Sabine Sparre} and Bente Glintborg and Oestergaard, {Louise Bruun} and Mette N{\o}rgaard and Thomas Benfield and Frank Mehnert and Andreas Petersen and Hetland, {Merete Lund}",
note = "COPECARE",
year = "2019",
month = sep,
day = "1",
doi = "10.1136/bmjopen-2019-030999",
language = "English",
volume = "9",
pages = "e030999",
journal = "BMJ Paediatrics Open ",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "9",

}

RIS

TY - JOUR

T1 - Risk factors for Staphylococcus aureus bacteremia in patients with rheumatoid arthritis and incidence compared with the general population

T2 - protocol for a Danish nationwide observational cohort study

AU - Dieperink, Sabine Sparre

AU - Glintborg, Bente

AU - Oestergaard, Louise Bruun

AU - Nørgaard, Mette

AU - Benfield, Thomas

AU - Mehnert, Frank

AU - Petersen, Andreas

AU - Hetland, Merete Lund

N1 - COPECARE

PY - 2019/9/1

Y1 - 2019/9/1

N2 - INTRODUCTION: Staphylococcus aureus bacteremia (SAB) is an invasive infection with high mortality and morbidity. Rheumatoid arthritis (RA) is associated with increased risk of infections due to the disease per se and the use of antirheumatic treatments. Few minor studies have previously investigated risk of SAB in patients with RA and indicated increased risk compared with the general population. This nationwide observational study aims to investigate incidence of and risk factors for SAB in adult patients with RA compared with the general population. The effect of disease characteristics (eg, joint erosions, disease duration and activity), different antirheumatic treatments and smoking on SAB risk will be evaluated.METHODS AND ANALYSIS: All adults (>18 years of age) alive and living in Denmark in 1996-2017 will be identified in The Danish Civil Registration System. Incident patients with RA are identified in the Danish National Patient Registry (DNPR) and the nationwide rheumatology registry, DANBIO, in which information on, for example, antirheumatic treatments, disease characteristics and smoking is collected prospectively in routine care. Information on comorbidities, invasive procedures and prescribed drugs are identified in the DNPR and in The Register of Medicinal Product Statistics. Socioeconomic status is evaluated in national registers on income and education. Incident cases of first-time SAB are identified in The Danish National SAB Database. All registers are linked on an individual level by unique civil registration numbers. Incidence rates and incidence rate ratios will be analysed using Poisson regression models and the impact of possible risk factors will be evaluated.ETHICS AND DISSEMINATION: All data will be handled in accordance with the General Data Protection Regulation (EU) 2016/679. No ethical approval is necessary in Denmark when handling registry data only. The results will be presented in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology initiative in international peer-reviewed journals and at medical conferences.TRIAL REGISTRATION NUMBER: NCT03908086.

AB - INTRODUCTION: Staphylococcus aureus bacteremia (SAB) is an invasive infection with high mortality and morbidity. Rheumatoid arthritis (RA) is associated with increased risk of infections due to the disease per se and the use of antirheumatic treatments. Few minor studies have previously investigated risk of SAB in patients with RA and indicated increased risk compared with the general population. This nationwide observational study aims to investigate incidence of and risk factors for SAB in adult patients with RA compared with the general population. The effect of disease characteristics (eg, joint erosions, disease duration and activity), different antirheumatic treatments and smoking on SAB risk will be evaluated.METHODS AND ANALYSIS: All adults (>18 years of age) alive and living in Denmark in 1996-2017 will be identified in The Danish Civil Registration System. Incident patients with RA are identified in the Danish National Patient Registry (DNPR) and the nationwide rheumatology registry, DANBIO, in which information on, for example, antirheumatic treatments, disease characteristics and smoking is collected prospectively in routine care. Information on comorbidities, invasive procedures and prescribed drugs are identified in the DNPR and in The Register of Medicinal Product Statistics. Socioeconomic status is evaluated in national registers on income and education. Incident cases of first-time SAB are identified in The Danish National SAB Database. All registers are linked on an individual level by unique civil registration numbers. Incidence rates and incidence rate ratios will be analysed using Poisson regression models and the impact of possible risk factors will be evaluated.ETHICS AND DISSEMINATION: All data will be handled in accordance with the General Data Protection Regulation (EU) 2016/679. No ethical approval is necessary in Denmark when handling registry data only. The results will be presented in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology initiative in international peer-reviewed journals and at medical conferences.TRIAL REGISTRATION NUMBER: NCT03908086.

KW - Antirheumatic agents

KW - Bacteremia

KW - Rheumatoid arthritis

KW - Staphylococcus aureus

KW - Staphylococcus aureus bacteremia

UR - http://www.scopus.com/inward/record.url?scp=85071780317&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2019-030999

DO - 10.1136/bmjopen-2019-030999

M3 - Journal article

C2 - 31481566

VL - 9

SP - e030999

JO - BMJ Paediatrics Open

JF - BMJ Paediatrics Open

SN - 2044-6055

IS - 9

M1 - e30999

ER -

ID: 57916545