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Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus

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Harvard

Knudsen, AD, Ronit, A, Kristensen, T, Thomsen, MT, Lebech, A-M, Pham, MHC, Sigvardsen, P, KÜhl, JT, Fuchs, A, KØber, L, Lundgren, J, Vestbo, J, Kofoed, KF & Nielsen, SD 2021, 'Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus', The Journal of infectious diseases, bind 223, nr. 1, jiaa339, s. 94-100. https://doi.org/10.1093/infdis/jiaa339

APA

Knudsen, A. D., Ronit, A., Kristensen, T., Thomsen, M. T., Lebech, A-M., Pham, M. H. C., Sigvardsen, P., KÜhl, J. T., Fuchs, A., KØber, L., Lundgren, J., Vestbo, J., Kofoed, K. F., & Nielsen, S. D. (2021). Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus. The Journal of infectious diseases, 223(1), 94-100. [jiaa339]. https://doi.org/10.1093/infdis/jiaa339

CBE

Knudsen AD, Ronit A, Kristensen T, Thomsen MT, Lebech A-M, Pham MHC, Sigvardsen P, KÜhl JT, Fuchs A, KØber L, Lundgren J, Vestbo J, Kofoed KF, Nielsen SD. 2021. Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus. The Journal of infectious diseases. 223(1):94-100. https://doi.org/10.1093/infdis/jiaa339

MLA

Vancouver

Author

Knudsen, Andreas D ; Ronit, Andreas ; Kristensen, Thomas ; Thomsen, Magda Teresa ; Lebech, Anne-Mette ; Pham, Michael Huy Cuong ; Sigvardsen, Per ; KÜhl, Jørgen Tobias ; Fuchs, Andreas ; KØber, Lars ; Lundgren, Jens ; Vestbo, Jørgen ; Kofoed, Klaus F ; Nielsen, Susanne D. / Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus. I: The Journal of infectious diseases. 2021 ; Bind 223, Nr. 1. s. 94-100.

Bibtex

@article{636f66ba524042b7b7431ba131bc82fa,
title = "Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus",
abstract = "Background: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with human immunodeficiency virus HIV (PWH) and uninfected controls. Methods: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of >1 between the diameter of the main pulmonary artery (at the level of its bifurcation) and the diameter of the ascending aorta. Results: In total, 900 PWH were included, and 44 (5%) had a pulmonary artery-aorta ratio (PA:A) >1. After adjustment for age, sex, and body mass index, obesity (adjusted odds ratio, 4.33; 95% confidence interval, 1.76-10.65; P =. 001) and injection drug use (IDU) (4.90; 1.00-18.46; P =. 03) were associated with higher odds of having a PA:A >1, and pulmonary indices and smoking status were not. HIV seropositivity was borderline associated with a PA:A >1 (adjusted odds ratio, 1.89; 95% confidence interval,. 92-3.85; P =. 08). Conclusions: A PA:A >1 was common in PWH. Obesity and IDU were independently associated with this finding and HIV serostatus was borderline associated with it, but HIV-related factors were not. Increased awareness may be appropriate in obese PWH and those with IDU.",
keywords = "Computed Tomography, HCV co-infection, HIV, Persons With HIV, Pulmonary Arterial Enlargement, Pulmonary Hypertension, computed tomography, persons with HIV, HCV coinfection, pulmonary hypertension, pulmonary arterial enlargement",
author = "Knudsen, {Andreas D} and Andreas Ronit and Thomas Kristensen and Thomsen, {Magda Teresa} and Anne-Mette Lebech and Pham, {Michael Huy Cuong} and Per Sigvardsen and K{\"U}hl, {J{\o}rgen Tobias} and Andreas Fuchs and Lars K{\O}ber and Jens Lundgren and J{\o}rgen Vestbo and Kofoed, {Klaus F} and Nielsen, {Susanne D}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2021",
month = jan,
day = "1",
doi = "10.1093/infdis/jiaa339",
language = "English",
volume = "223",
pages = "94--100",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "University of Chicago Press",
number = "1",

}

RIS

TY - JOUR

T1 - Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus

AU - Knudsen, Andreas D

AU - Ronit, Andreas

AU - Kristensen, Thomas

AU - Thomsen, Magda Teresa

AU - Lebech, Anne-Mette

AU - Pham, Michael Huy Cuong

AU - Sigvardsen, Per

AU - KÜhl, Jørgen Tobias

AU - Fuchs, Andreas

AU - KØber, Lars

AU - Lundgren, Jens

AU - Vestbo, Jørgen

AU - Kofoed, Klaus F

AU - Nielsen, Susanne D

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Background: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with human immunodeficiency virus HIV (PWH) and uninfected controls. Methods: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of >1 between the diameter of the main pulmonary artery (at the level of its bifurcation) and the diameter of the ascending aorta. Results: In total, 900 PWH were included, and 44 (5%) had a pulmonary artery-aorta ratio (PA:A) >1. After adjustment for age, sex, and body mass index, obesity (adjusted odds ratio, 4.33; 95% confidence interval, 1.76-10.65; P =. 001) and injection drug use (IDU) (4.90; 1.00-18.46; P =. 03) were associated with higher odds of having a PA:A >1, and pulmonary indices and smoking status were not. HIV seropositivity was borderline associated with a PA:A >1 (adjusted odds ratio, 1.89; 95% confidence interval,. 92-3.85; P =. 08). Conclusions: A PA:A >1 was common in PWH. Obesity and IDU were independently associated with this finding and HIV serostatus was borderline associated with it, but HIV-related factors were not. Increased awareness may be appropriate in obese PWH and those with IDU.

AB - Background: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with human immunodeficiency virus HIV (PWH) and uninfected controls. Methods: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of >1 between the diameter of the main pulmonary artery (at the level of its bifurcation) and the diameter of the ascending aorta. Results: In total, 900 PWH were included, and 44 (5%) had a pulmonary artery-aorta ratio (PA:A) >1. After adjustment for age, sex, and body mass index, obesity (adjusted odds ratio, 4.33; 95% confidence interval, 1.76-10.65; P =. 001) and injection drug use (IDU) (4.90; 1.00-18.46; P =. 03) were associated with higher odds of having a PA:A >1, and pulmonary indices and smoking status were not. HIV seropositivity was borderline associated with a PA:A >1 (adjusted odds ratio, 1.89; 95% confidence interval,. 92-3.85; P =. 08). Conclusions: A PA:A >1 was common in PWH. Obesity and IDU were independently associated with this finding and HIV serostatus was borderline associated with it, but HIV-related factors were not. Increased awareness may be appropriate in obese PWH and those with IDU.

KW - Computed Tomography

KW - HCV co-infection

KW - HIV

KW - Persons With HIV

KW - Pulmonary Arterial Enlargement

KW - Pulmonary Hypertension

KW - computed tomography

KW - persons with HIV

KW - HCV coinfection

KW - pulmonary hypertension

KW - pulmonary arterial enlargement

UR - http://www.scopus.com/inward/record.url?scp=85099428108&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiaa339

DO - 10.1093/infdis/jiaa339

M3 - Journal article

C2 - 32561921

VL - 223

SP - 94

EP - 100

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

M1 - jiaa339

ER -

ID: 60097395