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Hvidovre Hospital - en del af Københavns Universitetshospital

Protective potential of high-intensity interval training on cardiac structure and function after COVID-19: protocol and statistical analysis plan for an investigator-blinded randomised controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Iben Elmerdahl Rasmussen
  • Frederik Foged
  • Josephine Bjørn Budde
  • Rasmus Syberg Rasmussen
  • Villads Rasmussen
  • Mark Lyngbæk
  • Simon Jønck
  • Rikke Krogh-Madsen
  • Birgitte Lindegaard
  • Mathias Ried-Larsen
  • Peter Godsk Jørgensen
  • Morten Asp Vonsild Lund
  • Lars Køber
  • Niels Vejlstrup
  • Bente Klarlund Pedersen
  • Ronan M G Berg
  • Regitse Højgaard Christensen
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INTRODUCTION: COVID-19 is associated with a marked systemic inflammatory response with concomitant cardiac injury and remodelling, but it is currently unknown whether the latter is reversible. Given that high-intensity interval training (HIIT) is a powerful stimulus to improve cardiorespiratory fitness while also eliciting marked anti-inflammatory effects, it may be an important countermeasure of reducing cardiopulmonary morbidity following COVID-19.

METHODS AND ANALYSIS: 40 COVID-19 survivors who have been discharged from hospital will be included in this investigator-blinded randomised study with a 12-week HIIT intervention. Patients will be 1:1 block-randomised by sex to either a supervised HIIT exercise group or standard care (control group). The main hypothesis is that a 12-week HIIT scheme is a safe way to improve loss of cardiac mass and associated cardiorespiratory fitness, despite hypothesised limited HIIT-induced changes in conventional lung function indices per se. Ultimately, we hypothesise that the HIIT scheme will reduce post-COVID-19 symptoms and improve quality of life.

ETHICS AND DISSEMINATION: This study is approved by the Scientific Ethical Committee at the Capital Region of Denmark (H-20033733, including amendments 75068 and 75799) and registered at (NCT04647734, pre-results). The findings will be published in a peer-reviewed journal, including cases of positive, negative and inconclusive results.Trial registration number NCT04549337.

TidsskriftBMJ Open
Udgave nummer11
Sider (fra-til)1-10
Antal sider10
StatusUdgivet - 18 nov. 2021

Bibliografisk note

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 69225697