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Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

Novel Anti-inflammatory Treatments in Cirrhosis. A Literature-Based Study

Publikation: Bidrag til tidsskriftReviewpeer review

DOI

  1. Disease-Specific Enteric Microbiome Dysbiosis in Inflammatory Bowel Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. Fecal microbiota transplantation in hepatic encephalopathy: a systematic review

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Alkoholassocieret levercirrose og relaterede komplikationer

    Publikation: Bidrag til tidsskriftReviewpeer review

Vis graf over relationer

Liver cirrhosis is a disease characterised by multiple complications and a poor prognosis. The prevalence is increasing worldwide. Chronic inflammation is ongoing in liver cirrhosis. No cure for the inflammation is available, and the current treatment of liver cirrhosis is only symptomatic. However, several different medical agents have been suggested as potential healing drugs. The majority are tested in rodents, but few human trials are effectuated. This review focuses on medical agents described in the literature with supposed alleviating and curing effects on liver cirrhosis. Twelve anti-inflammatory, five antioxidative, and three drugs with effects on gut microflora and the LPS pathway were found. Two drugs not categorised by the three former categories were found in addition. In total, 42 rodent studies and seven human trials were found. Promising effects of celecoxib, aspirin, curcumin, kahweol, pentoxifylline, diosmin, statins, emricasan, and silymarin were found in cirrhotic rodent models. Few indices of effects of etanercept, glycyrrhizin arginine salt, and mitoquinone were found. Faecal microbiota transplantation is in increasing searchlight with a supposed potential to alleviate cirrhosis. However, human trials are in demand to verify the findings in this review.

OriginalsprogEngelsk
Artikelnummer718896
TidsskriftFrontiers in Medicine
Vol/bind8
Sider (fra-til)1-19
Antal sider19
ISSN2296-858X
DOI
StatusUdgivet - 23 sep. 2021

Bibliografisk note

Copyright © 2021 Kronborg, Ytting, Hobolth, Møller and Kimer.

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