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Hvidovre Hospital - en del af Københavns Universitetshospital
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Mechanisms and factors that influence high frequency retroviral recombination

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  • Krista Delviks-Frankenberry
  • Andrea Galli
  • Olga Nikolaitchik
  • Helene Mens
  • Vinay K Pathak
  • Wei-Shau Hu
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With constantly changing environmental selection pressures, retroviruses rely upon recombination to reassort polymorphisms in their genomes and increase genetic diversity, which improves the chances for the survival of their population. Recombination occurs during DNA synthesis, whereby reverse transcriptase undergoes template switching events between the two copackaged RNAs, resulting in a viral recombinant with portions of the genetic information from each parental RNA. This review summarizes our current understanding of the factors and mechanisms influencing retroviral recombination, fidelity of the recombination process, and evaluates the subsequent viral diversity and fitness of the progeny recombinant. Specifically, the high mutation rates and high recombination frequencies of HIV-1 will be analyzed for their roles in influencing HIV-1 global diversity, as well as HIV-1 diagnosis, drug treatment, and vaccine development.
OriginalsprogEngelsk
TidsskriftViruses
Vol/bind3
Udgave nummer9
Sider (fra-til)1650-80
Antal sider31
ISSN1999-4915
DOI
StatusUdgivet - 2011

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