Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Magnesium sulphate treatment decreases the risk of cerebral palsy after preterm birth
AU - Wolf, Hanne Trap
AU - Henriksen, Tine Brink
AU - Larsen, Mads Langager
AU - Pinborg, Anja
AU - Hegaard, Hanne Kristine
AU - Brok, Jesper Sune
AU - Huusom, Lene Drasbek
PY - 2020/11/16
Y1 - 2020/11/16
N2 - Children born preterm have an increased risk of severe morbidity, e.g. cerebral palsy (CP), compared to children born at term. CP cannot be treated, which is why a prophylactic approach is essential, as argued in this review. Six randomised controlled trials (RCTs) have provided data on MgSO4 treatment as CP neuroprotection in preterm birth, including a new RCT from Denmark. Recently, an updated meta-analysis with trial sequential analysis detected a significant neuroprotective effect of MgSO4 treatment in preterm birth. There is now sufficient evidence, that MgSO4 treatment should be used as neuroprotection in preterm birth.
AB - Children born preterm have an increased risk of severe morbidity, e.g. cerebral palsy (CP), compared to children born at term. CP cannot be treated, which is why a prophylactic approach is essential, as argued in this review. Six randomised controlled trials (RCTs) have provided data on MgSO4 treatment as CP neuroprotection in preterm birth, including a new RCT from Denmark. Recently, an updated meta-analysis with trial sequential analysis detected a significant neuroprotective effect of MgSO4 treatment in preterm birth. There is now sufficient evidence, that MgSO4 treatment should be used as neuroprotection in preterm birth.
KW - Cerebral Palsy/prevention & control
KW - Child
KW - Female
KW - Humans
KW - Infant, Newborn
KW - Magnesium Sulfate/therapeutic use
KW - Neuroprotection
KW - Neuroprotective Agents/therapeutic use
KW - Pregnancy
KW - Premature Birth/prevention & control
KW - Prenatal Care
KW - Randomized Controlled Trials as Topic
M3 - Journal article
C2 - 33215580
VL - 182
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 47
ER -
ID: 61730534