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Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease

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  • S Loft
  • K Simonsen
  • T Evald
  • H R Christensen
  • J Sonne
  • M Døssing
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The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days. During prednisolone administration antipyrine clearance decreased from 54.9 +/- 14.8 to 51.7 +/- 14.6 ml/min (mean +/- SD; p less than 0.05). The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Pharmacology
Vol/bind33
Udgave nummer1
Sider (fra-til)89-91
Antal sider3
ISSN0031-6970
DOI
StatusUdgivet - 1987

ID: 67536705