Forskning
Udskriv Udskriv
Switch language
Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Cardiodynamic state is associated with systemic inflammation and fatal acute-on-chronic liver failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. Progressive resistance training prevents loss of muscle mass and strength in bile duct-ligated rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. A major outbreak of covid-19 at a residential care home

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1

    Publikation: Bidrag til tidsskriftReviewpeer review

Vis graf over relationer

BACKGROUND & AIMS: Shortening the treatment duration for chronic hepatitis C may increase feasibility and reduce the cost of cure. The aims of this study were to compare 4 weeks of glecaprevir/pibrentasvir (GLE/PIB) treatment with and without ribavirin for patients with chronic hepatitis C and favourable baseline characteristics and to monitor the development of resistance-associated substitutions (RAS) and re-treatment outcomes if treatment failed.

METHODS: We performed an open-label single-centre randomized controlled trial, in which patients with chronic hepatitis C were randomized 1:1 to GLE/PIB ± ribavirin, stratified by genotype 3. The main inclusion criteria were treatment-naive patients, aged 18-49 with all genotypes accepted, and absence of liver fibrosis, determined by liver stiffness measurement less than 8 kPa. Viral genome sequences were determined by deep sequencing at baseline and at the time of relapse.

RESULTS: A total of 32 patients started treatment. Sustained virological response at week 12 (SVR12) was 59% (10/17) for GLE/PIB without ribavirin and 73% (11/15) for GLE/PIB with ribavirin. Drug target-specific NS5A RAS were detected at baseline for 45% (5/11) of patients with treatment failure and for 14% (3/21) of patients who achieved SVR12. Ten failure patients were retreated 12 weeks with sofosbuvir-based regimens; all have been cured.

CONCLUSIONS: In this pilot study of 4-week treatment with GLE/PIB with and without ribavirin, we found that baseline RAS were more frequent in patients with virological failure. Development of RAS did occur after short treatment but did not result in retreatment failure with a different regimen. EudraCT no: 2017-005179-21.

OriginalsprogEngelsk
TidsskriftLiver international : official journal of the International Association for the Study of the Liver
Vol/bind41
Udgave nummer11
Sider (fra-til)2601-2610
Antal sider10
ISSN1478-3223
DOI
StatusUdgivet - nov. 2021

ID: 66421275