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Human Papillomavirus Testing in the Last Cervical Screening Round at Age 60-64 Years

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@article{f8f381fb0d2347d68c3e07b1a3aa405c,
title = "Human Papillomavirus Testing in the Last Cervical Screening Round at Age 60-64 Years",
abstract = "OBJECTIVE: To compare the real-life screening outcomes after cytology was replaced by human papillomavirus (HPV) testing for women aged 60-64 years.METHODS: Using the Danish national pathology register, we compared screening outcomes during two consecutive calendar periods, one where women were screened with cytology and one where most women were screened with HPV testing. Our primary outcomes were the proportions of women with positive test results, high-grade cervical intraepithelial neoplasia (CIN 2 or worse), and cervical cancer.RESULTS: Women screened during the HPV testing period were more likely to have a positive screening test result than were women screened during the cytology period (relative proportion 2.80, 95% CI 2.65-2.96). The detection of CIN 2 or worse was also increased (relative proportion 1.54, 95% CI 1.31-1.80), whereas there was no increase in screen-detected cervical cancer diagnoses (relative proportion 1.27, 95% CI 0.76-2.12). Within the first 4 years after a negative screening test result, including 168,477 woman-years at risk after a negative screen result in the HPV period and 451,421 woman-years after a negative screen result in the cytology period, the risk of a cervical cancer diagnosis was approximately 4 per 100,000 woman-years and was similar for both screening tests (relative risk 0.99, 95% CI 0.41-2.35).CONCLUSION: Human papillomavirus testing led to more positive screening test results and diagnoses of high-grade CIN lesions. Few women were diagnosed with cervical cancer after a negative screening test result.",
keywords = "Cervical Intraepithelial Neoplasia/epidemiology, Denmark/epidemiology, Female, Humans, Incidence, Middle Aged, Papillomaviridae/isolation & purification, Papillomavirus Infections/epidemiology, Registries, Uterine Cervical Neoplasms/epidemiology, Vaginal Smears",
author = "Schroll, {Jeppe Bennekou} and Serizawa, {Reza Rafiolsadat} and Matejka Rebolj",
note = "Copyright {\textcopyright} 2021 The Author(s). Published by Wolters Kluwer Health, Inc.",
year = "2021",
month = sep,
day = "1",
doi = "10.1097/AOG.0000000000004522",
language = "English",
volume = "138",
pages = "389--397",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Human Papillomavirus Testing in the Last Cervical Screening Round at Age 60-64 Years

AU - Schroll, Jeppe Bennekou

AU - Serizawa, Reza Rafiolsadat

AU - Rebolj, Matejka

N1 - Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - OBJECTIVE: To compare the real-life screening outcomes after cytology was replaced by human papillomavirus (HPV) testing for women aged 60-64 years.METHODS: Using the Danish national pathology register, we compared screening outcomes during two consecutive calendar periods, one where women were screened with cytology and one where most women were screened with HPV testing. Our primary outcomes were the proportions of women with positive test results, high-grade cervical intraepithelial neoplasia (CIN 2 or worse), and cervical cancer.RESULTS: Women screened during the HPV testing period were more likely to have a positive screening test result than were women screened during the cytology period (relative proportion 2.80, 95% CI 2.65-2.96). The detection of CIN 2 or worse was also increased (relative proportion 1.54, 95% CI 1.31-1.80), whereas there was no increase in screen-detected cervical cancer diagnoses (relative proportion 1.27, 95% CI 0.76-2.12). Within the first 4 years after a negative screening test result, including 168,477 woman-years at risk after a negative screen result in the HPV period and 451,421 woman-years after a negative screen result in the cytology period, the risk of a cervical cancer diagnosis was approximately 4 per 100,000 woman-years and was similar for both screening tests (relative risk 0.99, 95% CI 0.41-2.35).CONCLUSION: Human papillomavirus testing led to more positive screening test results and diagnoses of high-grade CIN lesions. Few women were diagnosed with cervical cancer after a negative screening test result.

AB - OBJECTIVE: To compare the real-life screening outcomes after cytology was replaced by human papillomavirus (HPV) testing for women aged 60-64 years.METHODS: Using the Danish national pathology register, we compared screening outcomes during two consecutive calendar periods, one where women were screened with cytology and one where most women were screened with HPV testing. Our primary outcomes were the proportions of women with positive test results, high-grade cervical intraepithelial neoplasia (CIN 2 or worse), and cervical cancer.RESULTS: Women screened during the HPV testing period were more likely to have a positive screening test result than were women screened during the cytology period (relative proportion 2.80, 95% CI 2.65-2.96). The detection of CIN 2 or worse was also increased (relative proportion 1.54, 95% CI 1.31-1.80), whereas there was no increase in screen-detected cervical cancer diagnoses (relative proportion 1.27, 95% CI 0.76-2.12). Within the first 4 years after a negative screening test result, including 168,477 woman-years at risk after a negative screen result in the HPV period and 451,421 woman-years after a negative screen result in the cytology period, the risk of a cervical cancer diagnosis was approximately 4 per 100,000 woman-years and was similar for both screening tests (relative risk 0.99, 95% CI 0.41-2.35).CONCLUSION: Human papillomavirus testing led to more positive screening test results and diagnoses of high-grade CIN lesions. Few women were diagnosed with cervical cancer after a negative screening test result.

KW - Cervical Intraepithelial Neoplasia/epidemiology

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Middle Aged

KW - Papillomaviridae/isolation & purification

KW - Papillomavirus Infections/epidemiology

KW - Registries

KW - Uterine Cervical Neoplasms/epidemiology

KW - Vaginal Smears

UR - http://www.scopus.com/inward/record.url?scp=85114753622&partnerID=8YFLogxK

U2 - 10.1097/AOG.0000000000004522

DO - 10.1097/AOG.0000000000004522

M3 - Journal article

C2 - 34352844

VL - 138

SP - 389

EP - 397

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -

ID: 66981983