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Hvidovre Hospital - en del af Københavns Universitetshospital
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Human Papillomavirus neutralizing and cross-reactive antibodies induced in HIV-positive subjects after vaccination with quadrivalent and bivalent HPV vaccines

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Helena Faust
  • Lars Toft
  • Peter Sehr
  • Martin Müller
  • Jesper Bonde
  • Ola Forslund
  • Lars Østergaard
  • Martin Tolstrup
  • Joakim Dillner
Vis graf over relationer

Ninety-one HIV-infected individuals (61 men and 30 women) were randomized to vaccination either with quadrivalent (Gardasil™) or bivalent (Cervarix™) HPV vaccine. Neutralizing and specific HPV-binding serum antibodies were measured at baseline and 12 months after the first vaccine dose. Presence of neutralizing and binding antibodies had good agreement (average Kappa for HPV types 6, 11, 16, 18, 31, 33 and 45 was 0.65). At baseline, 88% of subjects had antibodies against at least one genital HPV. Following vaccination with Cervarix™, all subjects became seropositive for HPV16 and 18. After Gardasil™ vaccination, 96% of subjects seroconverted for HPV16 and 73% for HPV18. Levels of HPV16-specific antibodies were <1 international unit (IU) in 87% of study subjects before vaccination but >10IU in 85% of study subjects after vaccination. Antibodies against non-vaccine HPV types appeared after Gardasil™ vaccination for >50% of vaccinated females for HPV 31, 35 and 73 and for >50% of Cervarix™-vaccinated females for HPV 31, 33, 35, 45, 56 and 58. Cross-reactivity with non-genital HPV types was also detected. In conclusion, HIV-infected subjects responded to HPV vaccination with induction of neutralizing antibodies against both vaccine and non-vaccine types.

OriginalsprogEngelsk
TidsskriftVaccine
Vol/bind34
Tidsskriftsnummer13
Sider (fra-til)1559-1565
ISSN0264-410X
DOI
StatusUdgivet - 16 feb. 2016

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