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Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections

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Harvard

Lawal, OU, Fraqueza, MJ, Bouchami, O, Worning, P, Bartels, MD, Gonçalves, ML, Paixão, P, Gonçalves, E, Toscano, C, Empel, J, Urbaś, M, Domínguez, MA, Westh, H, de Lencastre, H & Miragaia, M 2021, 'Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections', Emerging Infectious Diseases , bind 27, nr. 3, s. 880-893. https://doi.org/10.3201/eid2703.200852

APA

Lawal, O. U., Fraqueza, M. J., Bouchami, O., Worning, P., Bartels, M. D., Gonçalves, M. L., Paixão, P., Gonçalves, E., Toscano, C., Empel, J., Urbaś, M., Domínguez, M. A., Westh, H., de Lencastre, H., & Miragaia, M. (2021). Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections. Emerging Infectious Diseases , 27(3), 880-893. https://doi.org/10.3201/eid2703.200852

CBE

Lawal OU, Fraqueza MJ, Bouchami O, Worning P, Bartels MD, Gonçalves ML, Paixão P, Gonçalves E, Toscano C, Empel J, Urbaś M, Domínguez MA, Westh H, de Lencastre H, Miragaia M. 2021. Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections. Emerging Infectious Diseases . 27(3):880-893. https://doi.org/10.3201/eid2703.200852

MLA

Vancouver

Author

Lawal, Opeyemi U ; Fraqueza, Maria J ; Bouchami, Ons ; Worning, Peder ; Bartels, Mette D ; Gonçalves, Maria L ; Paixão, Paulo ; Gonçalves, Elsa ; Toscano, Cristina ; Empel, Joanna ; Urbaś, Małgorzata ; Domínguez, M Angeles ; Westh, Henrik ; de Lencastre, Hermínia ; Miragaia, Maria. / Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections. I: Emerging Infectious Diseases . 2021 ; Bind 27, Nr. 3. s. 880-893.

Bibtex

@article{f5a4026e49a94016933c42bb9f291dad,
title = "Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections",
abstract = "Staphylococcus saprophyticus is a primary cause of community-acquired urinary tract infections (UTIs) in young women. S. saprophyticus colonizes humans and animals but basic features of its molecular epidemiology are undetermined. We conducted a phylogenomic analysis of 321 S. saprophyticus isolates collected from human UTIs worldwide during 1997-2017 and 232 isolates from human UTIs and the pig-processing chain in a confined region during 2016-2017. We found epidemiologic and genomic evidence that the meat-production chain is a major source of S. saprophyticus causing human UTIs; human microbiota is another possible origin. Pathogenic S. saprophyticus belonged to 2 lineages with distinctive genetic features that are globally and locally disseminated. Pangenome-wide approaches identified a strong association between pathogenicity and antimicrobial resistance, phages, platelet binding proteins, and an increased recombination rate. Our study provides insight into the origin, transmission, and population structure of pathogenic S. saprophyticus and identifies putative new virulence factors.",
keywords = "Animals, Community-Acquired Infections, Humans, Staphylococcal Infections, Staphylococcus saprophyticus, Swine, Urinary Tract Infections, Virulence Factors",
author = "Lawal, {Opeyemi U} and Fraqueza, {Maria J} and Ons Bouchami and Peder Worning and Bartels, {Mette D} and Gon{\c c}alves, {Maria L} and Paulo Paix{\~a}o and Elsa Gon{\c c}alves and Cristina Toscano and Joanna Empel and Ma{\l}gorzata Urba{\'s} and Dom{\'i}nguez, {M Angeles} and Henrik Westh and {de Lencastre}, Herm{\'i}nia and Maria Miragaia",
year = "2021",
month = mar,
doi = "10.3201/eid2703.200852",
language = "English",
volume = "27",
pages = "880--893",
journal = "Emerging Infectious Diseases ",
issn = "1080-6040",
publisher = "U.S. Department of Health and Human Services Centers for Disease Control and Prevention",
number = "3",

}

RIS

TY - JOUR

T1 - Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections

AU - Lawal, Opeyemi U

AU - Fraqueza, Maria J

AU - Bouchami, Ons

AU - Worning, Peder

AU - Bartels, Mette D

AU - Gonçalves, Maria L

AU - Paixão, Paulo

AU - Gonçalves, Elsa

AU - Toscano, Cristina

AU - Empel, Joanna

AU - Urbaś, Małgorzata

AU - Domínguez, M Angeles

AU - Westh, Henrik

AU - de Lencastre, Hermínia

AU - Miragaia, Maria

PY - 2021/3

Y1 - 2021/3

N2 - Staphylococcus saprophyticus is a primary cause of community-acquired urinary tract infections (UTIs) in young women. S. saprophyticus colonizes humans and animals but basic features of its molecular epidemiology are undetermined. We conducted a phylogenomic analysis of 321 S. saprophyticus isolates collected from human UTIs worldwide during 1997-2017 and 232 isolates from human UTIs and the pig-processing chain in a confined region during 2016-2017. We found epidemiologic and genomic evidence that the meat-production chain is a major source of S. saprophyticus causing human UTIs; human microbiota is another possible origin. Pathogenic S. saprophyticus belonged to 2 lineages with distinctive genetic features that are globally and locally disseminated. Pangenome-wide approaches identified a strong association between pathogenicity and antimicrobial resistance, phages, platelet binding proteins, and an increased recombination rate. Our study provides insight into the origin, transmission, and population structure of pathogenic S. saprophyticus and identifies putative new virulence factors.

AB - Staphylococcus saprophyticus is a primary cause of community-acquired urinary tract infections (UTIs) in young women. S. saprophyticus colonizes humans and animals but basic features of its molecular epidemiology are undetermined. We conducted a phylogenomic analysis of 321 S. saprophyticus isolates collected from human UTIs worldwide during 1997-2017 and 232 isolates from human UTIs and the pig-processing chain in a confined region during 2016-2017. We found epidemiologic and genomic evidence that the meat-production chain is a major source of S. saprophyticus causing human UTIs; human microbiota is another possible origin. Pathogenic S. saprophyticus belonged to 2 lineages with distinctive genetic features that are globally and locally disseminated. Pangenome-wide approaches identified a strong association between pathogenicity and antimicrobial resistance, phages, platelet binding proteins, and an increased recombination rate. Our study provides insight into the origin, transmission, and population structure of pathogenic S. saprophyticus and identifies putative new virulence factors.

KW - Animals

KW - Community-Acquired Infections

KW - Humans

KW - Staphylococcal Infections

KW - Staphylococcus saprophyticus

KW - Swine

KW - Urinary Tract Infections

KW - Virulence Factors

UR - http://www.scopus.com/inward/record.url?scp=85101655624&partnerID=8YFLogxK

U2 - 10.3201/eid2703.200852

DO - 10.3201/eid2703.200852

M3 - Journal article

C2 - 33622483

VL - 27

SP - 880

EP - 893

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 3

ER -

ID: 68198293