Udskriv Udskriv
Switch language
Hvidovre Hospital - en del af Københavns Universitetshospital

First trimester PAPP-A2, PAPP-A and hCGβ in small-for-gestational-age pregnancies

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review


  1. Prenatal detection rate of major congenital heart defects in Copenhagen from 2015 to 2018

    Publikation: Bidrag til tidsskriftLetterpeer review

  2. Why we succeed and fail in detecting fetal growth restriction: A population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

BACKGROUND: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a recently discovered protease that cleaves a subset of insulin-like growth factor binding proteins (IGFBP). The molecular function suggests its involvement in the IGF system that is vital for fetal growth and development. Our objectives were to establish first trimester median curves of PAPP-A2, PAPP-A and hCGβ for singleton normal pregnancies and to investigate whether an altered level of one or more of the biomarkers is associated with small-for-gestational-age (SGA) neonates before and after stratification according to maternal hypertension and/or proteinuria.

METHODS: This was a case-control study based on 985 pregnant women delivering normal-weighted neonates and 170 pregnant women delivering SGA neonates. PAPP-A2 was measured by ELISA. PAPP-A and hCGβ were measured by an automatic analyzer. Median curves from 8+1 to 14+0 were established and all concentration values were converted to multiples of the median (MoM) values.

RESULTS: Before stratification the SGA cases had unaffected PAPP-A2 MoM and hCGβ MoM levels but lower PAPP-A MoM compared with normal controls. After stratification the SGA normotensive subgroup had lower PAPP-A2 MoM and PAPP-A MoM levels than the normal normotensive subgroup. Severe preeclamptic women delivering SGA neonates had higher PAPP-A2 MoM compared to the normotensive women delivering SGA neonates.

CONCLUSIONS: Pregnant women delivering SGA neonates did not have altered levels of PAPP-A2 or hCGβ but had lower PAPP-A level in the first trimester compared with pregnant women delivering normal-weighted neonates. Pregnancies complicated with severe preeclampsia and SGA may be associated with high PAPP-A2 level.

TidsskriftClinical Chemistry and Laboratory Medicine
Udgave nummer1
Sider (fra-til)117-23
Antal sider7
StatusUdgivet - jan. 2016

ID: 49463441