Forskning
Udskriv Udskriv
Switch language
Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

Factors associated with thymic size at birth among low and normal birth-weight infants

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. Clinical Features and Outcome of Ebola Virus Disease in Pediatric Patients: A Retrospective Case Series

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Admission Hypothermia in Very Preterm Infants and Neonatal Mortality and Morbidity

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Impact of fetal growth restriction on mortality and morbidity in a very preterm birth cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. A new mutation causing autosomal dominant periodic fever syndrome in a Danish family.

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. Characteristics of Danish children registered with and pharmacologically treated for hypertension

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Determinants of Bacille Calmette-Guérin scarification in Danish children

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Thymus size in children with moderate malnutrition: a cohort study from Burkina Faso

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

OBJECTIVE: To study the effect of gestational and perinatal exposures on thymic size in 366 normal birth weight and 426 low birth weight (LBW) neonates in Guinea-Bissau in West Africa.

STUDY DESIGN: In a cross-sectional study, thymic size was measured at birth by the use of ultrasound. Information on possible determinants was collected from pregnancy cards, hospital records, and interviews with the mother. We used the log-transformed thymic index and thymus/weight index as outcome measures. Data were analyzed with adjusted linear regression models providing geometric mean ratios (GMRs) with 95% CI.

RESULTS: Determinants of thymic size among normal birth weight infants were pathologic amniotic fluid (adjusted GMR for thymic index: 0.84 [0.74-0.96]) and male sex (GMR: 1.13 [1.06-1.22]). Among LBW infants, birth season (1.11 [1.01-1.22]), maternal body temperature (0.89 [0.79-0.98]), antibiotic treatment at the time of labor (0.84 [0.70-1.00]), number of pregnancy consultations (1.03 [1.00-1.05]), maternal age (0.91 [0.84-0.98]), Apgar score (1.06 [1.03-1.10]), and infant convulsions (0.44 [0.29-0.65]) were all independent determinants of thymic index but not all were determinants of thymus/weight index. Pathologic amniotic fluid and cesarean delivery were associated with thymus/weight index among LBW infants (0.85 [0.75-0.95] and 0.80 [0.67-0.96]) but were only borderline significant for thymic index.

CONCLUSION: Exposures mainly related to stress and infections were associated with a smaller thymus, mainly in LBW infants.

OriginalsprogEngelsk
TidsskriftThe Journal of pediatrics
Vol/bind165
Udgave nummer4
Sider (fra-til)713-21
Antal sider9
ISSN0022-3476
DOI
StatusUdgivet - okt. 2014

ID: 44861173