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Hvidovre Hospital - en del af Københavns Universitetshospital
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Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

Publikation: Bidrag til tidsskriftReviewpeer review

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SUMMARYGut bacteria play a key role in initiating and maintaining the inflammatory process in the gut tissues of inflammatory bowel disease (IBD) patients, by supplying antigens or other stimulatory factors that trigger immune cell activation. Changes in the composition of the intestinal microbiota in IBD patients compared to that in healthy controls and a reduced diversity of intestinal microbial species are linked to the pathogenesis of IBD. Adherent invasive Escherichia coli (AIEC) has been linked to Crohn's disease (CD) patients, while diffusely adherent E. coli (DAEC) has been associated with ulcerative colitis (UC). Bacteriological analysis of intestinal biopsy specimens and fecal samples from IBD patients shows an increased number of E. coli strains belonging to the B2 phylogenetic group, which are typically known as extraintestinal pathogenic E. coli (ExPEC). Results from studies of both cell cultures and animal models reveal pathogenic features of these E. coli pathobionts, which may link them to IBD pathogenesis. This suggests that IBD-associated E. coli strains play a facilitative role during IBD flares. In this review, we explain IBD-associated E. coli and its role in IBD pathogenesis.

OriginalsprogEngelsk
Artikelnummere00060-18
TidsskriftClinical Microbiology Reviews
Vol/bind32
Udgave nummer2
ISSN0893-8512
DOI
StatusUdgivet - 20 mar. 2019

ID: 56412789