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Hvidovre Hospital - en del af Københavns Universitetshospital
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Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw

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  • Dan Li
  • Kirill Gromov
  • Steven T Proulx
  • Chao Xie
  • Jie Li
  • Daniel P Crane
  • Kjeld Søballe
  • Regis J O'Keefe
  • Hani A Awad
  • Lianping Xing
  • Edward M Schwarz
Vis graf over relationer
The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant-associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected humoral immunity, angiogenesis, or chronic infection. However, the significant (P <0.05 vs. PBS) inhibition of cortical osteolysis and decreased draining lymph node size in Aln- and OPG-treated mice was associated with a significant (P <0.05) increase in the incidence of high-grade infections during the establishment of OM. In contrast, the high-grade infections in TNFR:Fc-treated mice were associated with immunosuppression, as evidenced by the absence of granulomas and presence of Gram(+) biofilm in the bone marrow. Collectively, these findings indicate that although antiresorptive agents do not exacerbate chronic OM, they can increase the bacterial load during early infection by decreasing lymphatic drainage and preventing the removal of necrotic bone that harbors the bacteria.
OriginalsprogEngelsk
TidsskriftNew York Academy of Sciences. Annals
Vol/bind1192
Sider (fra-til)84-94
Antal sider11
ISSN0077-8923
DOI
StatusUdgivet - 2010

ID: 36916546