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Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women

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Bendsen, Nathalie T ; Haugaard, Steen B ; Larsen, Thomas M ; Chabanova, Elizaveta ; Stender, Steen ; Astrup, Arne. / Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women. I: Metabolism. 2011 ; Bind 60, Nr. 7. s. 906-13.

Bibtex

@article{faa3b1f7992546a79fa6102ed2e053c5,
title = "Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women",
abstract = "Intake of industrially produced trans-fatty acids (TFA) has been linked to increased risk of type 2 diabetes mellitus in observational studies. We investigated the causality of this association by examining if a high intake of TFA impairs measures of glucose homeostasis and induces intramuscular lipid deposition in abdominally obese women. In a double-blind, parallel dietary intervention study, 52 healthy but overweight postmenopausal women were randomized to receive either partially hydrogenated soybean oil (15 g/d TFA) or a control oil (mainly oleic and palmitic acid) for 16 weeks. Three markers of glucose homeostasis and 4 markers of lipolysis were derived from glucose, insulin, C-peptide, nonesterified fatty acid, and glycerol concentrations during a 3-hour frequent sampling oral glucose tolerance test. Intramuscular lipids were assessed by magnetic resonance spectroscopy. Forty-nine women completed the study. Insulin sensitivity (assessed by ISI(composite)), β-cell function (the disposition index), and the metabolic clearance rate of insulin were not significantly affected by the dietary intervention. Neither was the ability of insulin to suppress plasma nonesterified fatty acid and glycerol during oral glucose ingestion nor the intramuscular lipid deposition. In conclusion, high TFA intake did not affect glucose metabolism over 16 weeks in postmenopausal overweight women. A study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA.",
keywords = "Aged, Blood Glucose, C-Peptide, Dietary Fats, Unsaturated, Fatty Acids, Nonesterified, Female, Glycerol, Homeostasis, Humans, Insulin, Insulin Resistance, Lipids, Middle Aged, Muscle, Skeletal, Oleic Acid, Overweight, Palmitic Acid, Postmenopause, Soybean Oil, Trans Fatty Acids",
author = "Bendsen, {Nathalie T} and Haugaard, {Steen B} and Larsen, {Thomas M} and Elizaveta Chabanova and Steen Stender and Arne Astrup",
note = "Copyright {\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = jul,
day = "1",
doi = "10.1016/j.metabol.2011.01.009",
language = "English",
volume = "60",
pages = "906--13",
journal = "Metabolism",
issn = "0026-0495",
publisher = "W.B./Saunders Co",
number = "7",

}

RIS

TY - JOUR

T1 - Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women

AU - Bendsen, Nathalie T

AU - Haugaard, Steen B

AU - Larsen, Thomas M

AU - Chabanova, Elizaveta

AU - Stender, Steen

AU - Astrup, Arne

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Intake of industrially produced trans-fatty acids (TFA) has been linked to increased risk of type 2 diabetes mellitus in observational studies. We investigated the causality of this association by examining if a high intake of TFA impairs measures of glucose homeostasis and induces intramuscular lipid deposition in abdominally obese women. In a double-blind, parallel dietary intervention study, 52 healthy but overweight postmenopausal women were randomized to receive either partially hydrogenated soybean oil (15 g/d TFA) or a control oil (mainly oleic and palmitic acid) for 16 weeks. Three markers of glucose homeostasis and 4 markers of lipolysis were derived from glucose, insulin, C-peptide, nonesterified fatty acid, and glycerol concentrations during a 3-hour frequent sampling oral glucose tolerance test. Intramuscular lipids were assessed by magnetic resonance spectroscopy. Forty-nine women completed the study. Insulin sensitivity (assessed by ISI(composite)), β-cell function (the disposition index), and the metabolic clearance rate of insulin were not significantly affected by the dietary intervention. Neither was the ability of insulin to suppress plasma nonesterified fatty acid and glycerol during oral glucose ingestion nor the intramuscular lipid deposition. In conclusion, high TFA intake did not affect glucose metabolism over 16 weeks in postmenopausal overweight women. A study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA.

AB - Intake of industrially produced trans-fatty acids (TFA) has been linked to increased risk of type 2 diabetes mellitus in observational studies. We investigated the causality of this association by examining if a high intake of TFA impairs measures of glucose homeostasis and induces intramuscular lipid deposition in abdominally obese women. In a double-blind, parallel dietary intervention study, 52 healthy but overweight postmenopausal women were randomized to receive either partially hydrogenated soybean oil (15 g/d TFA) or a control oil (mainly oleic and palmitic acid) for 16 weeks. Three markers of glucose homeostasis and 4 markers of lipolysis were derived from glucose, insulin, C-peptide, nonesterified fatty acid, and glycerol concentrations during a 3-hour frequent sampling oral glucose tolerance test. Intramuscular lipids were assessed by magnetic resonance spectroscopy. Forty-nine women completed the study. Insulin sensitivity (assessed by ISI(composite)), β-cell function (the disposition index), and the metabolic clearance rate of insulin were not significantly affected by the dietary intervention. Neither was the ability of insulin to suppress plasma nonesterified fatty acid and glycerol during oral glucose ingestion nor the intramuscular lipid deposition. In conclusion, high TFA intake did not affect glucose metabolism over 16 weeks in postmenopausal overweight women. A study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA.

KW - Aged

KW - Blood Glucose

KW - C-Peptide

KW - Dietary Fats, Unsaturated

KW - Fatty Acids, Nonesterified

KW - Female

KW - Glycerol

KW - Homeostasis

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Lipids

KW - Middle Aged

KW - Muscle, Skeletal

KW - Oleic Acid

KW - Overweight

KW - Palmitic Acid

KW - Postmenopause

KW - Soybean Oil

KW - Trans Fatty Acids

U2 - 10.1016/j.metabol.2011.01.009

DO - 10.1016/j.metabol.2011.01.009

M3 - Journal article

C2 - 21397284

VL - 60

SP - 906

EP - 913

JO - Metabolism

JF - Metabolism

SN - 0026-0495

IS - 7

ER -

ID: 32680525