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Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

Do substance P and vasoactive intestinal polypeptide (VIP) play a role in the acute occlusive or chronic ischaemic vasodilation in man?

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  • J H Henriksen
  • J B Bülow
  • Ove B. Schaffalitzky de Muckadell
  • J Fahrenkrug
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The concentrations of substance P (SP) and vasoactive intestinal polypeptide (VIP) were determined in plasma in normal volunteers during acute occlusive ischaemia (n=5) and in patients with chronic ischaemia (n=5) due to obliterative arterial disease in the lower limbs. Venous SP, but not VIP, increased significantly in the early post-occlusive period in normal volunteers (P less than 0.02). In the patients no significant veno-arterial difference in plasma concentration of SP or VIP could be detected across normal or chronic ischaemic areas. The results may suggest a role for SP in the acute post-occlusive vasodilation and/or in the post-occlusive heat-pain sensation. A role for SP in chronic ischaemia could not be defined. Plasma VIP was unchanged in both acute and chronic ischaemia.
OriginalsprogEngelsk
TidsskriftClinical physiology (Oxford, England)
Vol/bind6
Udgave nummer2
Sider (fra-til)163-70
Antal sider8
ISSN0144-5979
StatusUdgivet - apr. 1986

ID: 39027733