Forskning
Udskriv Udskriv
Switch language
Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

Dientamoeba fragilis - a Commensal in Children in Danish Day Care Centers

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Harvard

Jokelainen, P, Hebbelstrup Jensen, B, Andreassen, BU, Petersen, AM, Röser, D, Krogfelt, KA, Nielsen, HV & Stensvold, CR 2017, 'Dientamoeba fragilis - a Commensal in Children in Danish Day Care Centers', Journal of Clinical Microbiology, bind 55, nr. 6, s. 1707-1713. https://doi.org/10.1128/JCM.00037-17

APA

CBE

MLA

Vancouver

Author

Jokelainen, Pikka ; Hebbelstrup Jensen, Betina ; Andreassen, Bente Utoft ; Petersen, Andreas Munk ; Röser, Dennis ; Krogfelt, Karen A ; Nielsen, Henrik V ; Stensvold, Christen Rune. / Dientamoeba fragilis - a Commensal in Children in Danish Day Care Centers. I: Journal of Clinical Microbiology. 2017 ; Bind 55, Nr. 6. s. 1707-1713.

Bibtex

@article{b2e0180f464d45fe852f28708599700e,
title = "Dientamoeba fragilis - a Commensal in Children in Danish Day Care Centers",
abstract = "Dientamoeba fragilis is an intestinal protozoan of debated clinical significance. Here, we present cross-sectional and longitudinal observations on D. fragilis in children aged 0-6 years from a 1-year multi-day-care-center cohort study set in Copenhagen, Denmark. The inclusion period for the cohort was 2009-2012. Stool samples collected from the children were accompanied by questionnaires completed by the parents or guardians of the children. Using real-time PCR, D. fragilis was detected in the first stool sample from 97 (68.3%) of 142 children. We evaluated associations between seven plausible risk factors (age, gender, having siblings, having domestic animals at home, having had infant colic, recent history of intake of antibiotics, and recent history of travel abroad) as well as six reported symptoms (lack of appetite, nausea, vomiting, abdominal pain, weight loss, and diarrhea) and testing positive for D. fragilis The final multivariable model identified being >3 years old and having a history of recent traveling abroad as risk factors for testing positive for D. fragilis Moreover, univariable analyses indicated that having siblings was a risk factor. There was no statistical association between a recent history of gastrointestinal symptoms and testing positive for D. fragilis Among the 108 children who were represented by ≥ 2 samples and thus included in the longitudinal analysis, 32 tested negative on first sample and positive later, and the last sample from each of the 108 children was positive. The results are in support of D. fragilis being a common enteric commensal in this population.",
keywords = "Journal Article",
author = "Pikka Jokelainen and {Hebbelstrup Jensen}, Betina and Andreassen, {Bente Utoft} and Petersen, {Andreas Munk} and Dennis R{\"o}ser and Krogfelt, {Karen A} and Nielsen, {Henrik V} and Stensvold, {Christen Rune}",
note = "Copyright {\textcopyright} 2017 American Society for Microbiology.",
year = "2017",
month = jun,
day = "1",
doi = "10.1128/JCM.00037-17",
language = "English",
volume = "55",
pages = "1707--1713",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "6",

}

RIS

TY - JOUR

T1 - Dientamoeba fragilis - a Commensal in Children in Danish Day Care Centers

AU - Jokelainen, Pikka

AU - Hebbelstrup Jensen, Betina

AU - Andreassen, Bente Utoft

AU - Petersen, Andreas Munk

AU - Röser, Dennis

AU - Krogfelt, Karen A

AU - Nielsen, Henrik V

AU - Stensvold, Christen Rune

N1 - Copyright © 2017 American Society for Microbiology.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Dientamoeba fragilis is an intestinal protozoan of debated clinical significance. Here, we present cross-sectional and longitudinal observations on D. fragilis in children aged 0-6 years from a 1-year multi-day-care-center cohort study set in Copenhagen, Denmark. The inclusion period for the cohort was 2009-2012. Stool samples collected from the children were accompanied by questionnaires completed by the parents or guardians of the children. Using real-time PCR, D. fragilis was detected in the first stool sample from 97 (68.3%) of 142 children. We evaluated associations between seven plausible risk factors (age, gender, having siblings, having domestic animals at home, having had infant colic, recent history of intake of antibiotics, and recent history of travel abroad) as well as six reported symptoms (lack of appetite, nausea, vomiting, abdominal pain, weight loss, and diarrhea) and testing positive for D. fragilis The final multivariable model identified being >3 years old and having a history of recent traveling abroad as risk factors for testing positive for D. fragilis Moreover, univariable analyses indicated that having siblings was a risk factor. There was no statistical association between a recent history of gastrointestinal symptoms and testing positive for D. fragilis Among the 108 children who were represented by ≥ 2 samples and thus included in the longitudinal analysis, 32 tested negative on first sample and positive later, and the last sample from each of the 108 children was positive. The results are in support of D. fragilis being a common enteric commensal in this population.

AB - Dientamoeba fragilis is an intestinal protozoan of debated clinical significance. Here, we present cross-sectional and longitudinal observations on D. fragilis in children aged 0-6 years from a 1-year multi-day-care-center cohort study set in Copenhagen, Denmark. The inclusion period for the cohort was 2009-2012. Stool samples collected from the children were accompanied by questionnaires completed by the parents or guardians of the children. Using real-time PCR, D. fragilis was detected in the first stool sample from 97 (68.3%) of 142 children. We evaluated associations between seven plausible risk factors (age, gender, having siblings, having domestic animals at home, having had infant colic, recent history of intake of antibiotics, and recent history of travel abroad) as well as six reported symptoms (lack of appetite, nausea, vomiting, abdominal pain, weight loss, and diarrhea) and testing positive for D. fragilis The final multivariable model identified being >3 years old and having a history of recent traveling abroad as risk factors for testing positive for D. fragilis Moreover, univariable analyses indicated that having siblings was a risk factor. There was no statistical association between a recent history of gastrointestinal symptoms and testing positive for D. fragilis Among the 108 children who were represented by ≥ 2 samples and thus included in the longitudinal analysis, 32 tested negative on first sample and positive later, and the last sample from each of the 108 children was positive. The results are in support of D. fragilis being a common enteric commensal in this population.

KW - Journal Article

U2 - 10.1128/JCM.00037-17

DO - 10.1128/JCM.00037-17

M3 - Journal article

C2 - 28330885

VL - 55

SP - 1707

EP - 1713

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 6

ER -

ID: 50138647