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Decrease in all-cause 30-day mortality after bacteraemia over a 15-year period: A population-based cohort study in Denmark in 2000–2014

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Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979–0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982–0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period. Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.

TidsskriftInternational Journal of Environmental Research and Public Health
Udgave nummer11
StatusUdgivet - 2 jun. 2021

Bibliografisk note

Funding Information:
This study was conducted as part of our routine work. No author received research funding. M.K.A.H. received a 5000 SEK young researchers travel grant from the SSAC Foundation to participate in the 36th annual NSCMID meeting to present a poster with preliminary results. The SSAC Foundation had no impact on study design, collection, interpretation of the data, or publication.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright 2021 Elsevier B.V., All rights reserved.

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