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Hvidovre Hospital - en del af Københavns Universitetshospital
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Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort

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  • C Ryberg
  • E Rostrup
  • O B Paulson
  • F Barkhof
  • P Scheltens
  • E C W van Straaten
  • W M van der Flier
  • F Fazekas
  • R Schmidt
  • J M Ferro
  • H Baezner
  • T Erkinjuntti
  • H Jokinen
  • L-O Wahlund
  • A Poggesi
  • L Pantoni
  • D Inzitari
  • G Waldemar
  • LADIS study group
  • Bjørn Ebdrup
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The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance (p
OriginalsprogEngelsk
TidsskriftJournal of the Neurological Sciences
Vol/bind307
Udgave nummer1-2
Sider (fra-til)100-5
Antal sider6
ISSN0022-510X
DOI
StatusUdgivet - 2011

ID: 33223959