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Brief Report: Prevalence of Peripheral Artery Disease is Higher in Persons Living with HIV Compared to Uninfected Controls

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Knudsen, AD, Gelpi, M, Afzal, S, Ronit, A, Roen, A, Mocroft, A, Lundgren, J, Nordestgaard, B, Sillesen, H, Lebech, A-M, Køber, L, Kofoed, KF & Nielsen, SD 2018, 'Brief Report: Prevalence of Peripheral Artery Disease is Higher in Persons Living with HIV Compared to Uninfected Controls', Journal of Acquired Immune Deficiency Syndromes, bind 79, nr. 3, s. 381-385. https://doi.org/10.1097/QAI.0000000000001795

APA

Knudsen, A. D., Gelpi, M., Afzal, S., Ronit, A., Roen, A., Mocroft, A., Lundgren, J., Nordestgaard, B., Sillesen, H., Lebech, A-M., Køber, L., Kofoed, K. F., & Nielsen, S. D. (2018). Brief Report: Prevalence of Peripheral Artery Disease is Higher in Persons Living with HIV Compared to Uninfected Controls. Journal of Acquired Immune Deficiency Syndromes, 79(3), 381-385. https://doi.org/10.1097/QAI.0000000000001795

CBE

MLA

Vancouver

Author

Knudsen, Andreas D ; Gelpi, Marco ; Afzal, Shoaib ; Ronit, Andreas ; Roen, Ashley ; Mocroft, Amanda ; Lundgren, Jens ; Nordestgaard, Børge ; Sillesen, Henrik ; Lebech, Anne-Mette ; Køber, Lars ; Kofoed, Klaus F ; Nielsen, Susanne Dam. / Brief Report: Prevalence of Peripheral Artery Disease is Higher in Persons Living with HIV Compared to Uninfected Controls. I: Journal of Acquired Immune Deficiency Syndromes. 2018 ; Bind 79, Nr. 3. s. 381-385.

Bibtex

@article{47a144d7ed8b441fa7aae32c7540ee7d,
title = "Brief Report: Prevalence of Peripheral Artery Disease is Higher in Persons Living with HIV Compared to Uninfected Controls",
abstract = "OBJECTIVE: Ankle-brachial index (ABI) is an excellent tool for diagnosing peripheral artery disease (PAD). We aimed to determine the prevalence and risk factors for PAD in people living with HIV (PLWH) compared to uninfected controls. We hypothesized that prevalence of PAD would be higher among PLWH than among controls independent of traditional cardiovascular disease (CVD) risk factors.METHODS: PLWH aged ≥40 were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study. Sex and age matched uninfected controls were recruited from the Copenhagen General Population Study. We defined PAD as ankle-brachial index (ABI) ≤ 0.9 and assessed risk factors for PAD using logistic regression adjusting for age, sex, smoking status, dyslipidemia, diabetes, hypertension and hsCRP.RESULTS: Among 908 PLWH and 11,106 controls, PAD was detected in 112 (12% CI [95% 10-14]) and 623 (6% [95% 5-6]), respectively (p<0.001); odds ratio (OR)=2.4 [95% 1.9-2.9], adjusted OR=1.7 [95% 1.3-2.3, p<.001]. Traditional CVD risk factors, but not HIV-related variables were associated with PAD. The strength of the association between PAD and HIV tended to be higher with older age (p=0.052, adjusted test for interaction).CONCLUSION: Prevalence of PAD is higher among PLWH compared to uninfected controls, especially among older persons, and remains so after adjusting for traditional CVD risk factors. Our findings expand the evidence base that PLWH have excess arterial disease to also include PAD. The exact biological mechanisms causing this excess risk remain to be elucidated. Until then, focus on management of modifiable traditional risk factors is important.",
author = "Knudsen, {Andreas D} and Marco Gelpi and Shoaib Afzal and Andreas Ronit and Ashley Roen and Amanda Mocroft and Jens Lundgren and B{\o}rge Nordestgaard and Henrik Sillesen and Anne-Mette Lebech and Lars K{\o}ber and Kofoed, {Klaus F} and Nielsen, {Susanne Dam}",
year = "2018",
month = nov,
day = "1",
doi = "10.1097/QAI.0000000000001795",
language = "English",
volume = "79",
pages = "381--385",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Brief Report: Prevalence of Peripheral Artery Disease is Higher in Persons Living with HIV Compared to Uninfected Controls

AU - Knudsen, Andreas D

AU - Gelpi, Marco

AU - Afzal, Shoaib

AU - Ronit, Andreas

AU - Roen, Ashley

AU - Mocroft, Amanda

AU - Lundgren, Jens

AU - Nordestgaard, Børge

AU - Sillesen, Henrik

AU - Lebech, Anne-Mette

AU - Køber, Lars

AU - Kofoed, Klaus F

AU - Nielsen, Susanne Dam

PY - 2018/11/1

Y1 - 2018/11/1

N2 - OBJECTIVE: Ankle-brachial index (ABI) is an excellent tool for diagnosing peripheral artery disease (PAD). We aimed to determine the prevalence and risk factors for PAD in people living with HIV (PLWH) compared to uninfected controls. We hypothesized that prevalence of PAD would be higher among PLWH than among controls independent of traditional cardiovascular disease (CVD) risk factors.METHODS: PLWH aged ≥40 were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study. Sex and age matched uninfected controls were recruited from the Copenhagen General Population Study. We defined PAD as ankle-brachial index (ABI) ≤ 0.9 and assessed risk factors for PAD using logistic regression adjusting for age, sex, smoking status, dyslipidemia, diabetes, hypertension and hsCRP.RESULTS: Among 908 PLWH and 11,106 controls, PAD was detected in 112 (12% CI [95% 10-14]) and 623 (6% [95% 5-6]), respectively (p<0.001); odds ratio (OR)=2.4 [95% 1.9-2.9], adjusted OR=1.7 [95% 1.3-2.3, p<.001]. Traditional CVD risk factors, but not HIV-related variables were associated with PAD. The strength of the association between PAD and HIV tended to be higher with older age (p=0.052, adjusted test for interaction).CONCLUSION: Prevalence of PAD is higher among PLWH compared to uninfected controls, especially among older persons, and remains so after adjusting for traditional CVD risk factors. Our findings expand the evidence base that PLWH have excess arterial disease to also include PAD. The exact biological mechanisms causing this excess risk remain to be elucidated. Until then, focus on management of modifiable traditional risk factors is important.

AB - OBJECTIVE: Ankle-brachial index (ABI) is an excellent tool for diagnosing peripheral artery disease (PAD). We aimed to determine the prevalence and risk factors for PAD in people living with HIV (PLWH) compared to uninfected controls. We hypothesized that prevalence of PAD would be higher among PLWH than among controls independent of traditional cardiovascular disease (CVD) risk factors.METHODS: PLWH aged ≥40 were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study. Sex and age matched uninfected controls were recruited from the Copenhagen General Population Study. We defined PAD as ankle-brachial index (ABI) ≤ 0.9 and assessed risk factors for PAD using logistic regression adjusting for age, sex, smoking status, dyslipidemia, diabetes, hypertension and hsCRP.RESULTS: Among 908 PLWH and 11,106 controls, PAD was detected in 112 (12% CI [95% 10-14]) and 623 (6% [95% 5-6]), respectively (p<0.001); odds ratio (OR)=2.4 [95% 1.9-2.9], adjusted OR=1.7 [95% 1.3-2.3, p<.001]. Traditional CVD risk factors, but not HIV-related variables were associated with PAD. The strength of the association between PAD and HIV tended to be higher with older age (p=0.052, adjusted test for interaction).CONCLUSION: Prevalence of PAD is higher among PLWH compared to uninfected controls, especially among older persons, and remains so after adjusting for traditional CVD risk factors. Our findings expand the evidence base that PLWH have excess arterial disease to also include PAD. The exact biological mechanisms causing this excess risk remain to be elucidated. Until then, focus on management of modifiable traditional risk factors is important.

U2 - 10.1097/QAI.0000000000001795

DO - 10.1097/QAI.0000000000001795

M3 - Journal article

C2 - 29985264

VL - 79

SP - 381

EP - 385

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 3

ER -

ID: 54889346