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Hvidovre Hospital - en del af Københavns Universitetshospital
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Bioavailability and pharmacokinetics of isradipine after oral and intravenous administration: half-life shorter than expected?

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  • H R Christensen
  • K Antonsen
  • K Simonsen
  • A Lindekaer
  • J Bonde
  • H R Angelo
  • J P Kampmann
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Isradipine is a calcium channel-blocking agent of the dihydropyridine type, used in the treatment of hypertension. A terminal half-life of 8-9 hr has been reported, in several pharmacokinetic studies after oral administration of isradipine. In a yet unpublished study a much shorter half-life was observed, and the present trial was therefore conducted in order to estimate the half-life after intravenous administration of isradipine. The bioavailability was estimated as well. In a randomised cross-over design ten healthy young volunteers were given either isradipine orally or an intravenous infusion. The two study periods were separated by at least 3 days. Blood samples for measurement of isradipine concentration were collected for 10-12 hr after administration and half-life and bioavailability were estimated. Mean terminal half-life after intravenous administration was calculated to be 2.8 hr, and the bioavailability to be 0.28. None of the 10 subjects suffered from side effects. In the present intravenous study the half-life of isradipine seems to be of much shorter than demonstrated in previous oral studies.

OriginalsprogEngelsk
TidsskriftPharmacology and Toxicology
Vol/bind86
Udgave nummer4
Sider (fra-til)178-82
Antal sider5
ISSN0901-9928
DOI
StatusUdgivet - apr. 2000

ID: 67536415