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Hvidovre Hospital - en del af Københavns Universitetshospital

TECTO Trial: Treatment Effects of Family Based Cognitive Therapy in Children and Adolescents with Obsessive Compulsive Disorder

Projekt: Typer af projekterProjekt

  1. Dr. Uhre et al. Reply

    Publikation: Bidrag til tidsskriftLetterpeer review

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  • Pagsberg, Anne Katrine (Projektleder, organisatorisk)
  • Siebner, Hartwig R. (Projektleder, faglig)
  • Verhulst, Frank (Projektdeltager)
  • Vangkilde, Signe Allerup (Projektdeltager)
  • Thomsen, Per Hove (Projektdeltager)
  • Gluud, Christian (Projektdeltager)
  • Jakobsen, Janus Christian (Projektdeltager)
  • Lindschou, Jane (Projektdeltager)
  • Staal, Nina (Projektdeltager)
  • Plessen , Kerstin J (Projektdeltager)
  • Lønfeldt, Nicole Nadine (Projektdeltager)
  • Baladi Nejad, Ayna (Projektdeltager)
  • Baaré, William Frans Christian (Projektdeltager)
  • Andersen, Kasper Winther (Projektdeltager)
  • Uhre, Camilla Funch (Projektdeltager)
  • Pretzmann, Linea (Projektdeltager)
  • Hagstrøm, Julie (Projektdeltager)
  • Clemmesen, Iben (Projektdeltager)
  • Aaen Gudmandsen, Amanda (Projektdeltager)
  • Sommer Harboe, Gitte (Projektdeltager)
  • Hybel, Katja, Aarhus University Hospital, Danmark (Projektdeltager)
  • Jørgensen, Niklas Rye (Projektdeltager)
  • Clemmensen, Line, Denmark Technical University, DTU Compute, Danmark (Projektdeltager)
  • Bugge, Birgitte (Projektdeltager)
  • Christensen, Sofie Heidenheim (Projektdeltager)
  • Uhre, Valdemar Funch (Projektdeltager)
  • Thoustrup, Christine (Projektdeltager)
  • Korsbjerg, Nicoline (Projektdeltager)
  • Mora-Jensen, Cecilie (Projektdeltager)
  • Damløv Thorsen, Emilie (Projektdeltager)
  • Ritter, Melanie (Projektdeltager)
  • Espensen, Frederik Ganci (Projektdeltager)
  • Hougaard, Anton Harald (Projektdeltager)
  • Ingstrup, Helga (Projektdeltager)
  • Halberg, Klara Sofie Vangstrup (Projektdeltager)
  • Larsen, Katrin Frimann (Projektdeltager)
  • Lydolff, Anne (Projektdeltager)
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Intro:
Cognitive behavioural therapy is the recommended first-line treatment for children and adolescents with obsessive-compulsive disorder. Evidence concerning beneficial and harmful effects compared with other interventions, and the underlying neurobiological, neurocognitive, and emotional mechanisms of action, have not yet been determined. Combining randomised clinical trials with neuroimaging methodology allows the determination of specific mediators of cognitive behavioural therapy. Such a design controls for potential non-specific therapeutic effects gained from factors such as attention to symptoms, and regular visits with a therapist. Objectives: To investigate the benefits and harms, and the neural, neurocognitive, neuroendocrine, and emotional mediators of treatment response, in family-based cognitive behavioural therapy versus family-based psychoeducation and relaxation training in children and adolescents with obsessive compulsive disorder. We aim to conduct this investigation in an optimal trial design with the lowest possible risk of bias.

Methods:
This trial is an investigator-initiated, independently funded, single-centre, parallel group superiority randomised clinical trial with blinded outcome assessment. The trial is combined with a case-control study, applying magnetic resonance imaging scans of the brain, immunoassays of salivary oxytocin, and neuropsychological and psychophysiological testing to participants with obsessive-compulsive disorder pre-, during, and post-treatment.

Results (expected):
Results from this trial, positive, negative as well as inconclusive, will be published in peer-reviewed scientific journals and presented at national and international congresses and workshops as soon as the data are analysed.

Discussion/Impact (expected):
Our systematic review of CBT trials in paediatric OCD showed that the overall ROB in previous randomised trials was significantly high. Even though certain elements of bias cannot be avoided due to the nature of psychotherapeutic intervention, others can be addressed and reduced (attrition bias, balancing interventions and avoiding competing interests). Futhermore, the question of how CBT treatment effects the central nervous system and mediates the response is not known. Therefore, it is ethically justifiable to investigate CBT as the experimental intervention in this trial. It is imperative to include children and adolscents in OCD trials because models of OCD etiology and of treatment mechanisms in CBT for OCD proposed in adults cannot necessarily be extended to children and adolescents. Although OCD symptomatology is similar in children, adolescents and adults, there are important differences in developmental psychopathology. Children with OCD may not perceive their symptoms as excessive and unrealistic, which may affect motivation for treatment. Furthermore, children are more likely to suffer from comorbid disorders, have poorer frustration tolerance and coping abilities, and parents are more likely to be involved in the childs’ symptoms. OCD symptoms of children can affect the functional level of the family, and parents and close family members should therefore be involved in the treatment. To address these issues, it is necessary for research in psychotherapy to target younger age groups. The need for developmentally adapted treatment is reflected in the guidelines for treatment of OCD, in which they distinguish between recommendations of treatment for children and adolescents and treatment for adults. The differences between children and adults with OCD can also be seen neurologically, which gives rise to believe that a possible neural effect of psychotherapy may differ between children and adults. It is therefore important to investigate neurobiological, neurocognitive, and emotional mediators of psychotherapy for children. As OCD often develops in childhood and can become chronic if left untreated, early intervention is crucial.
StatusIgangværende
Periode27/07/201801/05/2028

    Forskningsområder

  • Sundhedsvidenskab - Anxiety Disorders, Phenomenology, Neuroimaging, Psychological Techniques, Psychotherapy, Biomarkers, Psychosocial Interventions, Recovery, Neurophysiology, Behavior and Behavior Mechanisms, Psychological assessment and psychometrics, Cognition, Randomized Controlled Clinical Trial, Observational study, Meta-Analysis

ID: 61797921