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Hvidovre Hospital - en del af Københavns Universitetshospital

Longitudinal study of working memory brain connectivity in antipsychotic drugnaive, first episode schizophrenia patients

Projekt: Typer af projekterProjekt

  1. Precision Brain-Circuit Therapy (Precision-BCT)

    Projekt: Typer af projekterProjekt

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Meta analyses have identified cognitive deficits to be the best predictors of functional outcome in patients affected by schizophrenia. Working memory (WM) dysfunction, in particular, represents a core cognitive deficit in schizophrenia. WM refers to the active maintenance and manipulation of information in a short timeframe in order to guide appropriate behavioral responses.
Neuroimaging studies in schizophrenia have traditionally focused on brain activation abnormalities during WM performance. More recently, changes in brain deactivations during WM tasks have been studied in schizophrenia patients. According to the resource reallocation theory, deactivation of task-unrelated areas occurs due to limited availability of neural resources. As task demands increase so does the activity of taskrelated areas which draw attentional resources away from task-unrelated areas resulting in an “anticorrelated”
activity profile between the competing networks. This project will look at whether dysfunctional deactivation is compensated for by the WM network in order for schizophrenia patients to achieve the same level of performance as healthy subjects. The project employs magnetic resonance imaging (MRI) of the brain to obtain a deeper understanding of cognitive dysfunction in the early stages of schizophrenia. Serial MRI measurements will assess changes in structural and functional brain connectivity within the neuronal network implicated in WM during the first six months of their schizophrenia diagnosis before and after mono-drug therapy with quetiapine. The project is designed to take a network perspective of brain function and determine (i) how the different components of
the WM activating and deactivating systems are connected, (ii) how these connections are dynamically modulated with increasing WM-load, and (iii) how an early disease state of schizophrenia modulates the connectivity among these regions.

ID: 32195266