26 Citations (Scopus)

Abstract

BACKGROUND: Atrial fibrillation is associated with inflammation. In contrast to inflammatory markers like C-reactive protein (CRP) and fibrinogen produced in the liver, YKL-40 is produced at the site of inflammation including in the myocardium. We hypothesized that elevated plasma YKL-40 levels associate with increased risk of atrial fibrillation. METHOD AND RESULTS: We measured plasma YKL-40 in 8731 participants from the prospective Copenhagen City Heart Study including 896 individuals who developed atrial fibrillation during up to 18years of follow-up. Additionally, we measured YKL-40 in 6621 individuals from the cross-sectional Copenhagen General Population Study including 337 cases with atrial fibrillation. A YKL-40 level >95% percentile (>204μg/L) versus 95% percentile versus
Original languageEnglish
JournalInternational Journal of Cardiology
Pages (from-to)154-9
Number of pages6
ISSN0167-5273
DOIs
Publication statusPublished - 2013

Fingerprint

Dive into the research topics of 'YKL-40 levels and atrial fibrillation in the general population'. Together they form a unique fingerprint.

Cite this