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Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity

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  1. PYY(3-36) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice

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  2. Nonsulfated cholecystokinins in cerebral neurons

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  3. PKA, novel PKC isoforms, and ERK is mediating PACAP auto-regulation via PAC1R in human neuroblastoma NB-1 cells

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  4. PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor

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  5. VIP/PACAP receptors in cerebral arteries of rat: characterization, localization and relation to intracellular calcium

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  1. Genterapi til sygdomme i centralnervesystemet

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  2. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

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  3. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

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  4. Towards automatic glaucoma assessment: An Encoder-decoder CNN for Retinal Layer Segmentation in Rodent OCT images

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  5. Short erythropoietin-derived peptide enhances memory, improves long-term potentiation, and counteracts amyloid beta-induced pathology

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Neuropeptide Y (NPY) has been implicated in anxiolytic- and antidepressant-like behaviour as well as seizure-suppressant effects in rodents. Although these effects appear to be predominantly mediated via other NPY receptors (Y1 and/or Y2), several studies have also indicated a role for Y5 receptors. Gene therapy using recombinant viral vectors to induce overexpression of NPY, Y1 or Y2 receptors in the hippocampus or amygdala has previously been shown to modulate emotional behaviour and seizures in rodents. The present study explored the potential effects of gene therapy with the Y5 receptor, by testing effects of recombinant adeno-associated viral vector (rAAV) encoding Y5 (rAAV-Y5) in anxiety- and depression-like behaviour as well as in kainate-induced seizures in adult mice. The rAAV-Y5 vector injected into the hippocampus and amygdala induced a pronounced and sustained increase in Y5 receptor mRNA expression and functional Y5 receptor binding, but no significant effects were found with regard to anxiety- and depression-like behaviours or seizure susceptibility. Instead, rAAV-mediated Y5 receptor transgene overexpression resulted in moderate hyperactivity in the open field test. These results do not support a potential role for single transgene overexpression of Y5 receptors for modulating anxiety-/depression-like behaviours or seizures in adult mice. Whether the induction of hyperactivity by rAAV-Y5 could be relevant for other conditions remains to be studied.
Original languageEnglish
JournalNeuropeptides (Edinburgh)
Volume46
Issue number2
Pages (from-to)71-9
Number of pages9
ISSN0143-4179
DOIs
Publication statusPublished - 2012

    Research areas

  • Amygdala, Animals, Anti-Anxiety Agents, Antidepressive Agents, Anxiety, Behavior, Animal, Depression, Gene Therapy, Genetic Vectors, Hippocampus, Hyperkinesis, Male, Mice, Mice, Inbred BALB C, Neuropeptide Y, Receptors, Neuropeptide Y, Seizures

ID: 36474620