Why cholecystokinin and gastrin are also incretins

Jens F. Rehfeld

doi:10.1097/XCE.0000000000000095

Why cholecystokinin and gastrin are also incretins

Jens F. Rehfeld

Department of Clinical Biochemistry

9 Citations (Scopus)

Abstract

This review argues that cholecystokinin (CCK) and gastrin are incretins. The insulin cells are equipped with CCK2/gastrin receptors. CCK/gastrin peptides stimulate insulin secretion and potentiate the incretin effect of glucagon-like peptide-1. CCK/gastrin and insulin are released in significant amounts during normal mixed meals even at modest changes in blood glucose concentrations. Treatment of diabetes patients with combinatorial glucagon-like peptide-1 and CCK or gastrin-derived constructs therefore provides an expedient option.

Original language	English
Journal	Cardiovascular Endocrinology
Volume	5
Issue number	3
Pages (from-to)	99-101
Number of pages	3
ISSN	2162-688X
DOIs	https://doi.org/10.1097/XCE.0000000000000095
Publication status	Published - 2016

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AB - This review argues that cholecystokinin (CCK) and gastrin are incretins. The insulin cells are equipped with CCK2/gastrin receptors. CCK/gastrin peptides stimulate insulin secretion and potentiate the incretin effect of glucagon-like peptide-1. CCK/gastrin and insulin are released in significant amounts during normal mixed meals even at modest changes in blood glucose concentrations. Treatment of diabetes patients with combinatorial glucagon-like peptide-1 and CCK or gastrin-derived constructs therefore provides an expedient option.

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ER -

Why cholecystokinin and gastrin are also incretins

Abstract

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