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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Why cholecystokinin and gastrin are also incretins

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This review argues that cholecystokinin (CCK) and gastrin are incretins. The insulin cells are equipped with CCK2/gastrin receptors. CCK/gastrin peptides stimulate insulin secretion and potentiate the incretin effect of glucagon-like peptide-1. CCK/gastrin and insulin are released in significant amounts during normal mixed meals even at modest changes in blood glucose concentrations. Treatment of diabetes patients with combinatorial glucagon-like peptide-1 and CCK or gastrin-derived constructs therefore provides an expedient option.
Original languageEnglish
JournalCardiovascular Endocrinology
Volume5
Issue number3
Pages (from-to)99-101
Number of pages3
ISSN2162-688X
DOIs
Publication statusPublished - 2016

ID: 49302265