Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

WHO grade I meningiomas: classification-tree for prognostic factors of survival

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Intracranial pressure before and after cranioplasty: insights into intracranial physiology

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Skull base versus non-skull base meningioma surgery in the elderly

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Meningiomas: skull base versus non-skull base

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Pathologic Characteristics of Pregnancy-Related Meningiomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Jean-Michel Lemée
  • Holger Joswig
  • Michele Da Broi
  • Marco Vincenzo Corniola
  • David Scheie
  • Karl Schaller
  • Eirik Helseth
  • Torstein R Meling
View graph of relations

World Health Organization (WHO) grade I meningiomas are intracranial extracerebral tumors, in which microsurgery as a stand-alone therapy provides high rates of disease control and low recurrence rates. Our aim was to identify prognostic factors of overall survival and time-to-retreat (OS; TTR) in a cohort of patients with surgically managed WHO grade I meningioma. Patients with WHO grade I meningiomas from a retrospectively (1990 to 2002) and prospectively managed (2003 to 2010) databank of Oslo University Hospital, Norway, were included. The mean follow-up was 9.2 ± 5.7 years, with a total of 11,414 patient-years. One thousand three hundred fifty-five patients were included. The mean age was 58 ± 13.2, mean Karnofsky Performance Status (KPS) 92.6 ± 26.1 and female-to-male ratio 2.5:1. The 1-year, 5-year, 10-year, 15-year, and 20-year probabilities were 0.98, 0.91, 0.87, 0.84, and 0.8 for TTR. Patient age (OR 0.92 [0.91, 0.94]), male sex (OR 0.59 [0.45, 0.76]), preoperative KPS ≥ 70 (OR 2.22 [1.59, 3.13]), skull base location (OR 0.77 [0.60, 1]), and the occurrence of a postoperative hematoma (OR 0.44 [0.26, 0.76]) were identified as independent prognostic factors of OS. Patient age (OR 1.02 [1.01, 1.03]) and skull base location (OR 0.30 [0.21, 0.45]) were independent predictors of decreased PFS. Using a recursive partitioning analysis, we suggest a classification tree for the prediction of 5-year PFS based on patient and tumor characteristics. The findings from this cohort of meningioma WHO I patients helps to identify patients at risk of recurrence and tailor the therapeutic management.

Original languageEnglish
JournalJournal of Neurosurgery
Volume43
Issue number2
Pages (from-to)749-758
Number of pages10
ISSN0022-3085
DOIs
Publication statusPublished - Apr 2020

    Research areas

  • Meningioma, Overall survival, Prognostic factors, Time-to-retreat, WHO grade I

ID: 59039543