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The Capital Region of Denmark - a part of Copenhagen University Hospital
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WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect--the Danish experience

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We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.

Original languageEnglish
JournalAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume123
Issue number9
Pages (from-to)787-92
Number of pages6
ISSN0903-4641
DOIs
Publication statusPublished - Sep 2015

    Research areas

  • Adult, Biopsy, Bone Marrow, Bone Marrow Neoplasms, Case-Control Studies, Humans, Myeloproliferative Disorders, World Health Organization, Young Adult

ID: 46023060