Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

White matter maturation during 12 months in individuals at ultra-high-risk for psychosis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Trajectory of cognitive functions in bipolar disorder: for better or worse?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Research output: Contribution to journalComment/debateResearchpeer-review

  4. Societal costs of Borderline Personality Disorders: a matched-controlled nationwide study of patients and spouses

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Meta-analysis of antidepressant effects of anti-inflammatory drugs-reply

    Research output: Contribution to journalComment/debateResearchpeer-review

  1. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effectiveness of cognitive remediation in the ultra-high risk state for psychosis

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations

OBJECTIVE: The neurodevelopmental hypothesis of psychosis suggests that disrupted white matter (WM) maturation underlies disease onset. In this longitudinal study, we investigated WM connectivity and compared WM changes between individuals at ultra-high-risk for psychosis (UHR) and healthy controls (HCs).

METHOD: Thirty UHR individuals and 23 HCs underwent MR diffusion tensor imaging before and after 12 months of non-manualized standard care. Positive and negative symptoms and level of functioning were assessed. Tract-based spatial statistics were employed.

RESULTS: During 12 months, none of the UHR individuals transitioned to psychosis. Both UHR individuals and HCs increased significantly in fractional anisotropy (FA). UHR individuals showed significant FA increases predominantly in the left superior longitudinal fasciculus (SLF) (P = 0.01), and HCs showed significant FA increases in the left uncinate fasciculus (P = 0.03). Within UHR individuals, a significant positive correlation between FA change and age was observed predominantly in the left SLF (P = 0.02). Within HCs, no significant correlation between FA change and age was observed. No significant correlations between baseline FA and clinical outcomes were observed; however, FA changes were significantly positively correlated to changes in negative symptoms (P = 0.04).

CONCLUSION: As normal brain maturation occurs in a posterior to frontal direction, our findings could suggest disturbed WM maturation in UHR individuals.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Volume137
Issue number1
Pages (from-to)65-78
Number of pages14
ISSN0001-690X
DOIs
Publication statusPublished - Jan 2018

    Research areas

  • Journal Article

ID: 52703935