Abstract
In a retrospective study of 84 children with standard-risk acute lymphoblastic leukemia diagnosed in 1981-1986, mean white cell count (mWBC) during maintenance chemotherapy (MT) was found to be significantly related to risk of hematological relapse, giving patients with the higher mWBC the poorer outcome. The only other significant relapse-related risk factor was white-cell count at diagnosis. mWBC was not significantly related to white cell count at diagnosis, sex, age, or dose of methotrexate or mercaptopurine. Patients with low mWBC also had relatively low white-cell counts after cessation of therapy when compared with patients with high mWBC.
| Original language | English |
|---|---|
| Journal | Pediatric Hematology and Oncology |
| Volume | 5 |
| Issue number | 4 |
| Pages (from-to) | 259-67 |
| Number of pages | 9 |
| ISSN | 0888-0018 |
| DOIs | |
| Publication status | Published - 1988 |
| Externally published | Yes |
Keywords
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use
- Child
- Child, Preschool
- Humans
- Leukocyte Count/drug effects
- Mercaptopurine/administration & dosage
- Methotrexate/administration & dosage
- Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood
- Prognosis
- Recurrence
- Remission Induction/methods
- Retrospective Studies
- Risk Factors