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The Capital Region of Denmark - a part of Copenhagen University Hospital
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What is the real incidence of vestibular schwannoma?

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  • Mirko Tos
  • Sven-Eric Stangerup
  • Per Cayé-Thomasen
  • Tina Tos
  • Jens Thomsen
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OBJECTIVES: To present the incidence of vestibular schwannoma (VS) in Denmark, compare the incidence with that of previous periods, and discuss the real incidence of VS.

DESIGN, SETTING, AND PATIENTS: Prospective registration of all diagnosed VS in Denmark, with a population of 5.1 to 5.2 million, during the 6 years from January 1996 through December 2001. Incidence in this period was compared with that of 3 previous periods (July 1976 through June 1983 [first period], July 1983 through June 1990 [second period], and July 1990 through December 1995 [third period]).

RESULTS: In the 1996-2001 period, 542 cases of VS were diagnosed, representing a mean incidence of 17.4 VS/1 million inhabitants per year. Of these, 227 tumors underwent operation, 14 underwent irradiation, and 301 were allocated to observation (wait-and-scan policy). One hundred sixty-six tumors were intrameatal. Size of extrameatal tumors was small in 104; medium in 194; large in 68; and giant (>40 mm) in 10. Compared with incidences of 7.8 VS/1 million inhabitants per year in the first, 9.4 VS/1 million inhabitants in the second, and 12.4 VS/1 million inhabitants in the third periods, the incidence for the 1996-2001 period represents an increase to 17.4 VS/1 million inhabitants per year. The mean incidence for the entire 25.5-year period was 11.5 VS/1 million inhabitants per year.

CONCLUSIONS: An estimate of a realistic mean incidence of VS depends on the observation period. Our 25.5-year registration of an entire population showed a mean incidence of 11.5 VS/1 million inhabitants per year. However, the latest period registered represents an incidence of 17.4 VS/1 million inhabitants per year, which, combined with a probable further increase of diagnosed tumors in forthcoming years, suggests a realistic incidence of approximately 13 VS/1 million inhabitants per year.

Original languageEnglish
JournalArchives of Otolaryngology - Head & Neck Surgery
Volume130
Issue number2
Pages (from-to)216-20
Number of pages5
ISSN0886-4470
DOIs
Publication statusPublished - Feb 2004

    Research areas

  • Denmark, Humans, Incidence, Neuroma, Acoustic, Population Surveillance, Prospective Studies, Time Factors

ID: 45996533