Abstract
BACKGROUND: Cochrane Reviews are methodologically of high quality but the clinical relevance of analysed efficacy measures (EMs) should also be assessed.
METHODS: The clinical relevance of EMs used in one systematic Cochrane review of oral zolmitriptan for migraine headache was evaluated.
RESULTS: The following EMs were used: pain free at two hours (30%), headache relief at two hours (60%), sustained pain free for 24 hours (19%) and sustained headache relief for 24 hours (39%). These EMs were also used in four other Cochrane reviews of acute migraine treatment. Of these EMs sustained headache relief for 24 h is not judged clinically relevant.
CONCLUSION: Pain free and sustained pain free are clinically relevant, but the responses are rather low, demonstrating that there is a need for improvement of acute drug treatment in migraine.
| Original language | English |
|---|---|
| Journal | Cephalalgia : an international journal of headache |
| Volume | 35 |
| Issue number | 5 |
| Pages (from-to) | 457-459 |
| ISSN | 0333-1024 |
| DOIs | |
| Publication status | Published - 2015 |