Abstract
Recurrence was first recognised as a clinical problem in 1989 with the advent of sumatriptan. The history of recurrence in early sumatriptan randomised clinical trials is described. Recurrence has been ascribed to patient-dependent factors but experience with ergot alkaloids suggested that recurrence can also be treatment-dependent. Possible mechanisms for recurrence are discussed.
| Original language | English |
|---|---|
| Journal | Journal of Headache and Pain |
| Volume | 10 |
| Issue number | 5 |
| Pages (from-to) | 311-5 |
| Number of pages | 4 |
| ISSN | 1129-2369 |
| DOIs | |
| Publication status | Published - 2009 |
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