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Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results

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  • E E J G Aller
  • Thomas Meinert Larsen
  • Claus Holst
  • A K Lindroos
  • A Kafatos
  • A Pfeiffer
  • J A Martinez
  • T Handjieva-Darlenska
  • M Kunesova
  • S Stender
  • W H M Saris
  • A Astrup
  • M A van Baak
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Background:A high dietary protein (P) content and low glycemic index (LGI) have been suggested to be beneficial for weight management, but long-term studies are scarce.Objective:The DIOGENES randomized clinical trial investigated the effect of P and GI on weight loss maintenance in overweight or obese adults in eight centers across Europe. This study reports the 1-year results in two of the centers that extended the intervention to 1 year.Method:After an 8-week low-calorie diet (LCD), 256 adults (body mass index >27 kg m(-)(2)) were randomized to five ad libitum diets for 12 months: high P/LGI (HP/LGI), HP/high GI (HP/HGI), low P/LGI (LP/LGI), LP/HGI and a control diet. During the first 6 months, foods were provided for free through a shop system and during the whole 12-month period, subjects received guidance by a dietician. Primary outcome variable was the change in body weight over the 12-month intervention period.Results:During the LCD period, subjects lost 11.2 (10.8, 12.0) kg (mean (95% confidence interval (CI))). Average weight regain over the 12-month intervention period was 3.9 (95% CI 3.0-4.8) kg. Subjects on the HP diets regained less weight than subjects on the LP diets. The difference in weight regain after 1 year was 2.0 (0.4, 3.6) kg (P=0.017) (completers analysis, N=139) or 2.8 (1.4, 4.1) kg (P<0.001) (intention-to-treat analysis, N=256). No consistent effect of GI on weight regain was found. There were no clinically relevant differences in changes in cardiometabolic risk factors among diet groups.Conclusion:A higher protein content of an ad libitum diet improves weight loss maintenance in overweight and obese adults over 12 months.International Journal of Obesity advance online publication, 29 April 2014; doi:10.1038/ijo.2014.52.

Original languageEnglish
JournalInternational journal of obesity (2005)
Volume38
Issue number12
Pages (from-to)1511-1517
Number of pages7
ISSN0307-0565
DOIs
Publication statusPublished - 28 Mar 2014

Bibliographical note

2014 Dec;38(12):1511-7

ID: 44395735