Weight loss after gastric bypass surgery in women is followed by a metabolically favorable decrease in 11beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue

Kotryna Simonyte; Tommy Olsson; Ingmar Näslund; Jan-Erik Angelhed; Lars Lönn; Cecilia Mattsson; Eva Rask

doi:10.1210/jc.2009-2472

Weight loss after gastric bypass surgery in women is followed by a metabolically favorable decrease in 11beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue

Kotryna Simonyte, Tommy Olsson, Ingmar Näslund, Jan-Erik Angelhed, Lars Lönn, Cecilia Mattsson, Eva Rask

Department of Diagnostic Radiology

22 Citations (Scopus)

Abstract

The role of 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) in the pathogenesis of obesity has been elucidated in humans and in various rodent models. Obesity is accompanied by disturbances in glucocorticoid metabolism, circulating adipokine levels, and fatty acid (FA) reesterification. This study was undertaken to evaluate glucocorticoid metabolism in sc fat before and after weight loss and to explore putative associations between 11beta-HSD1 and leptin, adiponectin, and FA recycling.

Original language	English
Journal	The Journal of clinical endocrinology and metabolism
Volume	95
Issue number	7
Pages (from-to)	3527-31
Number of pages	5
DOIs	https://doi.org/10.1210/jc.2009-2472
Publication status	Published - 1 Jul 2010

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Simonyte, K., Olsson, T., Näslund, I., Angelhed, J.-E., Lönn, L., Mattsson, C., & Rask, E. (2010). Weight loss after gastric bypass surgery in women is followed by a metabolically favorable decrease in 11beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue. The Journal of clinical endocrinology and metabolism, 95(7), 3527-31. https://doi.org/10.1210/jc.2009-2472

Weight loss after gastric bypass surgery in women is followed by a metabolically favorable decrease in 11beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue. / Simonyte, Kotryna; Olsson, Tommy; Näslund, Ingmar et al.
In: The Journal of clinical endocrinology and metabolism, Vol. 95, No. 7, 01.07.2010, p. 3527-31.

Research output: Contribution to journal › Journal article › Research › peer-review

Simonyte, K, Olsson, T, Näslund, I, Angelhed, J-E, Lönn, L, Mattsson, C & Rask, E 2010, 'Weight loss after gastric bypass surgery in women is followed by a metabolically favorable decrease in 11beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue', The Journal of clinical endocrinology and metabolism, vol. 95, no. 7, pp. 3527-31. https://doi.org/10.1210/jc.2009-2472

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Weight loss after gastric bypass surgery in women is followed by a metabolically favorable decrease in 11beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue

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