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Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy-Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort

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@article{2efde446ca75448b8c238b6546952359,
title = "Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy-Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort",
abstract = "Women with breast cancer are a growing population due to improved screening and treatment. It has been described that chemotherapy can negatively affect patients' metabolism. The aim of this study is to assess weight gain during chemotherapy treatment in an interim analysis on an ongoing prospective cohort of women with early breast cancer. To help untangle the many possible reasons for weight change, we examine blood tests, Patient-Reported Outcomes (PROs), and bone mineral density (BMD). We find that the 38 women that have measurements taken after chemotherapy have an average weight gain of 1.2 kg although not significant. Together with this, there is a significant drop in HDL cholesterol, an increase in triglycerides, and a non-significant tendency towards decreased insulin sensitivity. PROs show that although the women experience more pain and fatigue, they have higher activity levels. BMD is at an expected level according to age. All in all, we see an increased focus on physical activity and nutrition, leading to less severe metabolic changes as previously reported. However, even though more measures are taken, we still see an overall negative metabolic impact with unknown long-term implications.",
keywords = "Aged, Antineoplastic Agents/adverse effects, Biomarkers/blood, Bone Remodeling/drug effects, Breast Neoplasms/drug therapy, Chemotherapy, Adjuvant, Diet, Healthy, Energy Metabolism/drug effects, Exercise, Female, Humans, Insulin Resistance, Lipids/blood, Middle Aged, Nutritional Status, Nutritive Value, Patient Reported Outcome Measures, Postmenopause, Prospective Studies, Time Factors, Treatment Outcome, Weight Gain/drug effects, Body weight, Nutrition, Breast cancer, Metabolism, Chemotherapy, Patient-reported outcomes",
author = "Kristian Buch-Larsen and Trine Lund-Jacobsen and Michael Andersson and Peter Schwarz",
year = "2021",
month = aug,
day = "23",
doi = "10.3390/nu13082902",
language = "English",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "8",

}

RIS

TY - JOUR

T1 - Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy-Perspectives on Nutrition, Activity and Bone Metabolism

T2 - An Interim Analysis of a 5-Year Prospective Cohort

AU - Buch-Larsen, Kristian

AU - Lund-Jacobsen, Trine

AU - Andersson, Michael

AU - Schwarz, Peter

PY - 2021/8/23

Y1 - 2021/8/23

N2 - Women with breast cancer are a growing population due to improved screening and treatment. It has been described that chemotherapy can negatively affect patients' metabolism. The aim of this study is to assess weight gain during chemotherapy treatment in an interim analysis on an ongoing prospective cohort of women with early breast cancer. To help untangle the many possible reasons for weight change, we examine blood tests, Patient-Reported Outcomes (PROs), and bone mineral density (BMD). We find that the 38 women that have measurements taken after chemotherapy have an average weight gain of 1.2 kg although not significant. Together with this, there is a significant drop in HDL cholesterol, an increase in triglycerides, and a non-significant tendency towards decreased insulin sensitivity. PROs show that although the women experience more pain and fatigue, they have higher activity levels. BMD is at an expected level according to age. All in all, we see an increased focus on physical activity and nutrition, leading to less severe metabolic changes as previously reported. However, even though more measures are taken, we still see an overall negative metabolic impact with unknown long-term implications.

AB - Women with breast cancer are a growing population due to improved screening and treatment. It has been described that chemotherapy can negatively affect patients' metabolism. The aim of this study is to assess weight gain during chemotherapy treatment in an interim analysis on an ongoing prospective cohort of women with early breast cancer. To help untangle the many possible reasons for weight change, we examine blood tests, Patient-Reported Outcomes (PROs), and bone mineral density (BMD). We find that the 38 women that have measurements taken after chemotherapy have an average weight gain of 1.2 kg although not significant. Together with this, there is a significant drop in HDL cholesterol, an increase in triglycerides, and a non-significant tendency towards decreased insulin sensitivity. PROs show that although the women experience more pain and fatigue, they have higher activity levels. BMD is at an expected level according to age. All in all, we see an increased focus on physical activity and nutrition, leading to less severe metabolic changes as previously reported. However, even though more measures are taken, we still see an overall negative metabolic impact with unknown long-term implications.

KW - Aged

KW - Antineoplastic Agents/adverse effects

KW - Biomarkers/blood

KW - Bone Remodeling/drug effects

KW - Breast Neoplasms/drug therapy

KW - Chemotherapy, Adjuvant

KW - Diet, Healthy

KW - Energy Metabolism/drug effects

KW - Exercise

KW - Female

KW - Humans

KW - Insulin Resistance

KW - Lipids/blood

KW - Middle Aged

KW - Nutritional Status

KW - Nutritive Value

KW - Patient Reported Outcome Measures

KW - Postmenopause

KW - Prospective Studies

KW - Time Factors

KW - Treatment Outcome

KW - Weight Gain/drug effects

KW - Body weight

KW - Nutrition

KW - Breast cancer

KW - Metabolism

KW - Chemotherapy

KW - Patient-reported outcomes

UR - http://www.scopus.com/inward/record.url?scp=85113789171&partnerID=8YFLogxK

U2 - 10.3390/nu13082902

DO - 10.3390/nu13082902

M3 - Journal article

C2 - 34445061

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 8

M1 - 2902

ER -

ID: 67834396