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Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy-Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort

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  2. Why do women with eating disorders decline treatment? A qualitative study of barriers to specialized eating disorder treatment

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  3. Associations between Postprandial Gut Hormones and Markers of Bone Remodeling

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  1. Mortality from cardiovascular disease in women with breast cancer - a nationwide registry study

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  2. Denosumab vs. zoledronic acid treatment in post-menopausal breast cancer: a 2-year prospective observational study

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  3. Cardiovascular disease in women with breast cancer - a nationwide cohort study

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  4. Republished: Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis

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  5. HER2-positiv metastatisk brystkræft

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Women with breast cancer are a growing population due to improved screening and treatment. It has been described that chemotherapy can negatively affect patients' metabolism. The aim of this study is to assess weight gain during chemotherapy treatment in an interim analysis on an ongoing prospective cohort of women with early breast cancer. To help untangle the many possible reasons for weight change, we examine blood tests, Patient-Reported Outcomes (PROs), and bone mineral density (BMD). We find that the 38 women that have measurements taken after chemotherapy have an average weight gain of 1.2 kg although not significant. Together with this, there is a significant drop in HDL cholesterol, an increase in triglycerides, and a non-significant tendency towards decreased insulin sensitivity. PROs show that although the women experience more pain and fatigue, they have higher activity levels. BMD is at an expected level according to age. All in all, we see an increased focus on physical activity and nutrition, leading to less severe metabolic changes as previously reported. However, even though more measures are taken, we still see an overall negative metabolic impact with unknown long-term implications.

Original languageEnglish
Article number2902
JournalNutrients
Volume13
Issue number8
ISSN2072-6643
DOIs
Publication statusPublished - 23 Aug 2021

    Research areas

  • Aged, Antineoplastic Agents/adverse effects, Biomarkers/blood, Bone Remodeling/drug effects, Breast Neoplasms/drug therapy, Chemotherapy, Adjuvant, Diet, Healthy, Energy Metabolism/drug effects, Exercise, Female, Humans, Insulin Resistance, Lipids/blood, Middle Aged, Nutritional Status, Nutritive Value, Patient Reported Outcome Measures, Postmenopause, Prospective Studies, Time Factors, Treatment Outcome, Weight Gain/drug effects, Body weight, Nutrition, Breast cancer, Metabolism, Chemotherapy, Patient-reported outcomes

ID: 67834396