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Water filtration of the forearm in short- and long-term diabetes mellitus

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@article{ec106f642e994cc0a6916f634f986871,
title = "Water filtration of the forearm in short- and long-term diabetes mellitus",
abstract = "Blood flow and capillary filtration coefficient (CFC) were measured by strain-gauge plethysmography on the upper and lower third of the forearm in 9 normal subjects and 29 well regulated patients with diabetes mellitus of varying duration (less than 10 years, 10 to 20 years, and more than 20 years). There was no difference in blood flow in the four groups, but CFC was significantly increased in long-term diabetes (duration above 20 years) when measured at the distal part of the forearm near the wrist. Calculations showed that this was probably due to the relatively high contribution of connective tissue in this part of the forearm. Increased water filtration in connective tissue in long-term diabetics is in accordance with earlier findings of a lowered subcutaneous interstitial fluid albumin concentration in long-term diabetics, this being explained by an increase in net water outflux from the microcirculation.",
keywords = "Body Water, Capillary Permeability, Connective Tissue, Diabetic Angiopathies, Forearm, Humans, Muscles, Regional Blood Flow, Time Factors",
author = "Poulsen, {H L} and Nielsen, {S L}",
year = "1976",
month = oct,
language = "English",
volume = "12",
pages = "437--40",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Water filtration of the forearm in short- and long-term diabetes mellitus

AU - Poulsen, H L

AU - Nielsen, S L

PY - 1976/10

Y1 - 1976/10

N2 - Blood flow and capillary filtration coefficient (CFC) were measured by strain-gauge plethysmography on the upper and lower third of the forearm in 9 normal subjects and 29 well regulated patients with diabetes mellitus of varying duration (less than 10 years, 10 to 20 years, and more than 20 years). There was no difference in blood flow in the four groups, but CFC was significantly increased in long-term diabetes (duration above 20 years) when measured at the distal part of the forearm near the wrist. Calculations showed that this was probably due to the relatively high contribution of connective tissue in this part of the forearm. Increased water filtration in connective tissue in long-term diabetics is in accordance with earlier findings of a lowered subcutaneous interstitial fluid albumin concentration in long-term diabetics, this being explained by an increase in net water outflux from the microcirculation.

AB - Blood flow and capillary filtration coefficient (CFC) were measured by strain-gauge plethysmography on the upper and lower third of the forearm in 9 normal subjects and 29 well regulated patients with diabetes mellitus of varying duration (less than 10 years, 10 to 20 years, and more than 20 years). There was no difference in blood flow in the four groups, but CFC was significantly increased in long-term diabetes (duration above 20 years) when measured at the distal part of the forearm near the wrist. Calculations showed that this was probably due to the relatively high contribution of connective tissue in this part of the forearm. Increased water filtration in connective tissue in long-term diabetics is in accordance with earlier findings of a lowered subcutaneous interstitial fluid albumin concentration in long-term diabetics, this being explained by an increase in net water outflux from the microcirculation.

KW - Body Water

KW - Capillary Permeability

KW - Connective Tissue

KW - Diabetic Angiopathies

KW - Forearm

KW - Humans

KW - Muscles

KW - Regional Blood Flow

KW - Time Factors

M3 - Journal article

C2 - 976633

VL - 12

SP - 437

EP - 440

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 5

ER -

ID: 44336136