Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate?: HLA haplotype observations of hemochromatosis from the west coast of Sweden

Karl Sigvard Olsson; Jan Konar; Inge Hoegh Dufva; Anne Ricksten; Ruma Raha-Chowdhury

doi:10.1111/j.1600-0609.2010.01536.x

Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate? HLA haplotype observations of hemochromatosis from the west coast of Sweden

Karl Sigvard Olsson, Jan Konar, Inge Hoegh Dufva, Anne Ricksten, Ruma Raha-Chowdhury

13 Citations (Scopus)

Abstract

The HLA-related hemochromatosis mutation C282Y is thought to have originated in Ireland in a person with HLA-A3-B14 and was spread by Vikings. Irish people with two HLA-A3 alleles had a high risk of hemochromatosis. In this study, from west Sweden, we wanted to test these hypotheses.

Original language	English
Journal	European Journal of Haematology
Volume	86
Issue number	1
Pages (from-to)	75-82
Number of pages	8
ISSN	0902-4441
DOIs	https://doi.org/10.1111/j.1600-0609.2010.01536.x
Publication status	Published - 2011

Keywords

Case-Control Studies
Europe
Founder Effect
Gene Frequency
Genetics, Population
Genotype
HLA-A3 Antigen
Haplotypes
Hemochromatosis
History, Medieval
Humans
Ireland
Linkage Disequilibrium
Mutation, Missense
Pedigree
Sweden

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10.1111/j.1600-0609.2010.01536.x

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Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate? HLA haplotype observations of hemochromatosis from the west coast of Sweden. / Olsson, Karl Sigvard; Konar, Jan; Dufva, Inge Hoegh et al.
In: European Journal of Haematology, Vol. 86, No. 1, 2011, p. 75-82.

Research output: Contribution to journal › Journal article › Research › peer-review

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Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate? HLA haplotype observations of hemochromatosis from the west coast of Sweden

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Keywords

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