Abstract
The HLA-related hemochromatosis mutation C282Y is thought to have originated in Ireland in a person with HLA-A3-B14 and was spread by Vikings. Irish people with two HLA-A3 alleles had a high risk of hemochromatosis. In this study, from west Sweden, we wanted to test these hypotheses.
Original language | English |
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Journal | European Journal of Haematology |
Volume | 86 |
Issue number | 1 |
Pages (from-to) | 75-82 |
Number of pages | 8 |
ISSN | 0902-4441 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Case-Control Studies
- Europe
- Founder Effect
- Gene Frequency
- Genetics, Population
- Genotype
- HLA-A3 Antigen
- Haplotypes
- Hemochromatosis
- History, Medieval
- Humans
- Ireland
- Linkage Disequilibrium
- Mutation, Missense
- Pedigree
- Sweden