Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate? HLA haplotype observations of hemochromatosis from the west coast of Sweden

Karl Sigvard Olsson, Jan Konar, Inge Hoegh Dufva, Anne Ricksten, Ruma Raha-Chowdhury

    13 Citations (Scopus)

    Abstract

    The HLA-related hemochromatosis mutation C282Y is thought to have originated in Ireland in a person with HLA-A3-B14 and was spread by Vikings. Irish people with two HLA-A3 alleles had a high risk of hemochromatosis. In this study, from west Sweden, we wanted to test these hypotheses.
    Original languageEnglish
    JournalEuropean Journal of Haematology
    Volume86
    Issue number1
    Pages (from-to)75-82
    Number of pages8
    ISSN0902-4441
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Case-Control Studies
    • Europe
    • Founder Effect
    • Gene Frequency
    • Genetics, Population
    • Genotype
    • HLA-A3 Antigen
    • Haplotypes
    • Hemochromatosis
    • History, Medieval
    • Humans
    • Ireland
    • Linkage Disequilibrium
    • Mutation, Missense
    • Pedigree
    • Sweden

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