Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study

Jakob Kirkegård; Frank Viborg Mortensen; Carsten Palnæs Hansen; Michael Bau Mortensen; Mogens Sall; Claus Fristrup

doi:10.1016/j.ejso.2019.05.029

Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study

Jakob Kirkegård, Frank Viborg Mortensen, Carsten Palnæs Hansen, Michael Bau Mortensen, Mogens Sall, Claus Fristrup

17 Citations (Scopus)

Abstract

INTRODUCTION: The effect of waiting time to surgery on survival in pancreatic cancer patients is unclear. We examined this association in a nationwide population-based cohort study.

MATERIALS AND METHODS: A nationwide population-based cohort study of all patients undergoing surgery for pancreatic cancer (resection or a palliative procedure) registered in the Danish Pancreatic Cancer Database from May 2011 to May 2016. We defined waiting time to surgery in two ways: 1) from the date of entry into the National Cancer Pathway to the date of surgery and 2) from the date of the last preoperative computed tomography (CT) or positron emission tomography (PET-CT) scan to the date of surgery. Waiting time was grouped into three groups: <28 days (<4 weeks), 28-55 days (4-8 weeks), and ≥56 days (≥8 weeks). We calculated median survival with associated 95% confidence intervals (CIs) for patients undergoing resection and for patients undergoing a palliative procedure.

RESULTS: We included 873 patients. Mean age was 67 years (range: 35-86 years). Resection was performed in 701 patients (80%); the remaining 172 patients (20%) underwent an explorative laparotomy or palliative surgery. 652 patients (75%) had a registration in the National Cancer Pathway (median waiting time: 31 days, and 818 patients (94%) had registration of a preoperative CT or PET-CT scan (median waiting time: 32 days). We saw similar resection rates (∼80%) and median survival (∼22 months) in all thee groups.

CONCLUSION: In this study, waiting time to surgery did not affect survival in patients undergoing surgery for pancreatic cancer.

Original language	English
Journal	European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Volume	45
Issue number	10
Pages (from-to)	1901-1905
Number of pages	5
ISSN	0748-7983
DOIs	https://doi.org/10.1016/j.ejso.2019.05.029
Publication status	Published - Oct 2019

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Kirkegård, J., Mortensen, F. V., Hansen, C. P., Mortensen, M. B., Sall, M., & Fristrup, C. (2019). Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 45(10), 1901-1905. https://doi.org/10.1016/j.ejso.2019.05.029

Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study. / Kirkegård, Jakob; Mortensen, Frank Viborg; Hansen, Carsten Palnæs et al.
In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Vol. 45, No. 10, 10.2019, p. 1901-1905.

Research output: Contribution to journal › Journal article › Research › peer-review

Kirkegård, J, Mortensen, FV, Hansen, CP, Mortensen, MB, Sall, M & Fristrup, C 2019, 'Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study', European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 45, no. 10, pp. 1901-1905. https://doi.org/10.1016/j.ejso.2019.05.029

Kirkegård J, Mortensen FV, Hansen CP, Mortensen MB, Sall M, Fristrup C. Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2019 Oct;45(10):1901-1905. doi: 10.1016/j.ejso.2019.05.029

Kirkegård, Jakob ; Mortensen, Frank Viborg ; Hansen, Carsten Palnæs et al. / Waiting time to surgery and pancreatic cancer survival : A nationwide population-based cohort study. In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2019 ; Vol. 45, No. 10. pp. 1901-1905.

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title = "Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study",

abstract = "INTRODUCTION: The effect of waiting time to surgery on survival in pancreatic cancer patients is unclear. We examined this association in a nationwide population-based cohort study.MATERIALS AND METHODS: A nationwide population-based cohort study of all patients undergoing surgery for pancreatic cancer (resection or a palliative procedure) registered in the Danish Pancreatic Cancer Database from May 2011 to May 2016. We defined waiting time to surgery in two ways: 1) from the date of entry into the National Cancer Pathway to the date of surgery and 2) from the date of the last preoperative computed tomography (CT) or positron emission tomography (PET-CT) scan to the date of surgery. Waiting time was grouped into three groups: <28 days (<4 weeks), 28-55 days (4-8 weeks), and ≥56 days (≥8 weeks). We calculated median survival with associated 95\% confidence intervals (CIs) for patients undergoing resection and for patients undergoing a palliative procedure.RESULTS: We included 873 patients. Mean age was 67 years (range: 35-86 years). Resection was performed in 701 patients (80\%); the remaining 172 patients (20\%) underwent an explorative laparotomy or palliative surgery. 652 patients (75\%) had a registration in the National Cancer Pathway (median waiting time: 31 days, and 818 patients (94\%) had registration of a preoperative CT or PET-CT scan (median waiting time: 32 days). We saw similar resection rates (∼80\%) and median survival (∼22 months) in all thee groups.CONCLUSION: In this study, waiting time to surgery did not affect survival in patients undergoing surgery for pancreatic cancer.",

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AU - Mortensen, Michael Bau

AU - Sall, Mogens

AU - Fristrup, Claus

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N2 - INTRODUCTION: The effect of waiting time to surgery on survival in pancreatic cancer patients is unclear. We examined this association in a nationwide population-based cohort study.MATERIALS AND METHODS: A nationwide population-based cohort study of all patients undergoing surgery for pancreatic cancer (resection or a palliative procedure) registered in the Danish Pancreatic Cancer Database from May 2011 to May 2016. We defined waiting time to surgery in two ways: 1) from the date of entry into the National Cancer Pathway to the date of surgery and 2) from the date of the last preoperative computed tomography (CT) or positron emission tomography (PET-CT) scan to the date of surgery. Waiting time was grouped into three groups: <28 days (<4 weeks), 28-55 days (4-8 weeks), and ≥56 days (≥8 weeks). We calculated median survival with associated 95% confidence intervals (CIs) for patients undergoing resection and for patients undergoing a palliative procedure.RESULTS: We included 873 patients. Mean age was 67 years (range: 35-86 years). Resection was performed in 701 patients (80%); the remaining 172 patients (20%) underwent an explorative laparotomy or palliative surgery. 652 patients (75%) had a registration in the National Cancer Pathway (median waiting time: 31 days, and 818 patients (94%) had registration of a preoperative CT or PET-CT scan (median waiting time: 32 days). We saw similar resection rates (∼80%) and median survival (∼22 months) in all thee groups.CONCLUSION: In this study, waiting time to surgery did not affect survival in patients undergoing surgery for pancreatic cancer.

AB - INTRODUCTION: The effect of waiting time to surgery on survival in pancreatic cancer patients is unclear. We examined this association in a nationwide population-based cohort study.MATERIALS AND METHODS: A nationwide population-based cohort study of all patients undergoing surgery for pancreatic cancer (resection or a palliative procedure) registered in the Danish Pancreatic Cancer Database from May 2011 to May 2016. We defined waiting time to surgery in two ways: 1) from the date of entry into the National Cancer Pathway to the date of surgery and 2) from the date of the last preoperative computed tomography (CT) or positron emission tomography (PET-CT) scan to the date of surgery. Waiting time was grouped into three groups: <28 days (<4 weeks), 28-55 days (4-8 weeks), and ≥56 days (≥8 weeks). We calculated median survival with associated 95% confidence intervals (CIs) for patients undergoing resection and for patients undergoing a palliative procedure.RESULTS: We included 873 patients. Mean age was 67 years (range: 35-86 years). Resection was performed in 701 patients (80%); the remaining 172 patients (20%) underwent an explorative laparotomy or palliative surgery. 652 patients (75%) had a registration in the National Cancer Pathway (median waiting time: 31 days, and 818 patients (94%) had registration of a preoperative CT or PET-CT scan (median waiting time: 32 days). We saw similar resection rates (∼80%) and median survival (∼22 months) in all thee groups.CONCLUSION: In this study, waiting time to surgery did not affect survival in patients undergoing surgery for pancreatic cancer.

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Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study

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