Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Waist circumference and low high-density lipoprotein cholesterol as markers of cardiometabolic risk in Kenyan adults

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Dancing with atrial fibrillation - How arrhythmia affects everyday life of family members: A qualitative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Endothelial glycocalyx and cardio-renal risk factors in type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prior undernutrition and insulin production several years later in Tanzanian adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Daniel Faurholt-Jepsen
  • Henrik Friis
  • David L. Mwaniki
  • Michael K. Boit
  • Lydia U. Kaduka
  • Inge Tetens
  • Dirk L. Christensen
View graph of relations

BACKGROUND: Abdominal obesity predict metabolic syndrome parameters at low levels of waist circumference (WC) in Africans. At the same time, the African lipid profile phenotype of low high-density lipoprotein (HDL) cholesterol without concomitant elevated triglyceride levels renders high triglyceride levels detrimental to cardiometabolic health unsuitable for identifying cardiometabolic risk in black African populations.

OBJECTIVES: We aimed to identify simple clinical measures for cardiometabolic risk based on WC and HDL in an adult Kenyan population in order to determine which of the two predictors had the strongest impact.

METHODS: We used linear regression analyses to assess the association between the two exposure variables WC and HDL with cardiometabolic risk factors including ultrasound-derived visceral (VAT) and subcutaneous adipose tissue (SAT) accumulation, fasting and 2-h venous glucose, fasting insulin, fasting lipid profile, and blood pressure in adult Kenyans (n = 1 370), and a sub-population with hyperglycaemia (diabetes and pre-diabetes) (n = 196). The same analyses were performed with an interaction between WC and HDL to address potential effect modification. Ultrasound-based, semi-quantitative hepatic steatosis assessment was used as a high-risk measure of cardiometabolic disease.

RESULTS: Mean age was 38.2 (SD 10.7) (range 17-68) years, mean body mass index was 22.3 (SD 4.5) (range 13.0-44.8) kg/m2, and 57.8% were women. Cardiometabolic risk was found in the association between both WC and HDL and all outcome variables (p<0.05) except for HDL and SAT, fasting and 2-h venous glucose. Additive cardiometabolic risk (WC and HDL interaction) was found for SAT, low-density lipoprotein cholesterol, and triglycerides. No differences in the association between WC and HDL and the outcome variables were found when comparing the full study population and the hyperglycaemia sub-population. Increase in WC and HDL were both associated with hepatic steatosis (OR 1.09, p<0.001, and OR 0.46, p = 0.031, respectively).

CONCLUSION: In adult Kenyans, increasing WC identified more cardiometabolic risk factors compared to HDL.

Original languageEnglish
Article numbere0247600
JournalPLoS One
Issue number2
Pages (from-to)e0247600
Publication statusPublished - Feb 2021

    Research areas

  • Adolescent, Adult, Aged, Cardiovascular Diseases/epidemiology, Cholesterol, HDL/blood, Female, Heart Disease Risk Factors, Humans, Kenya, Male, Metabolic Syndrome/epidemiology, Middle Aged, Obesity, Abdominal/epidemiology, Waist Circumference, Young Adult

ID: 66495940