Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Popliteal artery entrapment syndrome: ultrasound imaging, intraoperative findings, and clinical outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: Disruption of the endothelial lining may be one of the events linking intraluminal thrombus and abdominal aortic aneurysm growth. In the present study, we examined whether von Willebrand factor activity in plasma, contact proteins of blood coagulation, and inflammatory biomarkers may be associated with intraluminal thrombus volume in search of a biochemical marker of endothelial damage and thrombus size.

DESIGN: Prospective study, correlating potential endothelial biomarkers and intraluminal thrombus volume acquired by computed tomography angiography.

MATERIALS AND METHODS: Plasma was consecutively obtained from 38 patients with asymptomatic infrarenal abdominal aortic aneurysm. von Willebrand factor activity, thrombin generation time, factor XII, and prekallikrein concentration were measured in plasma on automated and in-house platforms. In total, 8 patients were excluded due to ongoing anticoagulant therapy, renal impairment, or nonappearance, thus leaving 30 patients for further analysis. All patients had computed tomography angiography, and intraluminal volume was quantified off-line by OsiriX 6.5.

RESULTS: Median intraluminal thrombus volume was 42.7 mL. Spearman correlation analysis revealed a positive correlation between thrombus volume, von Willebrand factor activity (ρ = 0.56, P = .0013), and prekallikrein concentration in plasma (ρ = 0.54, P = .002).

CONCLUSION: von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.

Original languageEnglish
JournalVascular and Endovascular Surgery
Issue number6
Pages (from-to)391-7
Number of pages7
Publication statusPublished - Aug 2016

    Research areas

  • Journal Article

ID: 48972713