Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The power of empirical data; lessons from the clinical registry initiatives in Scandinavian cancer care

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Biological optimization for mediastinal lymphoma radiotherapy - a preliminary study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. eHealth-mind the gap

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Tumour control probability after Ruthenium-106 brachytherapy for choroidal melanomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Use of primary health care and participation in colorectal cancer screening - a Danish national register-based study

    Research output: Contribution to journalLetterResearchpeer-review

  1. Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-term Consequences of Undiagnosed Celiac Seropositivity

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Vitamin D has a role in bone turnover and potentially bone-metastatic spread of prostate cancer (PCa). The aim of this observational study was to address the association between levels of serum vitamin D, diagnosis of PCa and subsequent mortality in men who underwent a biopsy of the prostate.

METHODS: All men who underwent prostatic biopsy in the Danish PCa Registry (DaPCaR) and who had a serum vitamin D measurement during the period 2004 to 2010 (n = 4,065) were identified. Men were categorized by clinical cut-offs based on seasonally adjusted serum vitamin D levels in <25 (deficient), 25-50 (insufficient), 50-75 (sufficient) and >75 nmol/L (high) serum vitamin D. Logistic regression model for association between vitamin D and risk of PCa diagnosis and multivariate survival analyses were applied.

RESULTS: No association between serum vitamin D and risk of PCa was found. Overall survival was lowest for serum vitamin D deficiency and a significantly higher PCa specific mortality (HR: 2.37, 95%CI: 1.45-3.90, p < .001) and other cause mortality (HR: 2.08, 95%CI: 1.33-3.24, p = .001) was found for PCa patients with serum vitamin D deficiency compared to serum vitamin D sufficiency.

CONCLUSION: No association was found between serum vitamin D categories and risk of PCa in men who underwent biopsy of the prostate. Men with PCa and serum vitamin D deficiency had a higher overall and PCa specific mortality compared to men with a sufficient level of serum vitamin D.

Original languageEnglish
JournalActa Oncologica
Pages (from-to)1-7
Number of pages7
ISSN0284-186X
DOIs
Publication statusE-pub ahead of print - 24 Oct 2020

    Research areas

  • epidemiology, mortality, Prostatic neoplasms, risk, Vitamin D

ID: 61115398